The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects.

What Was Tested

This controlled clinical trial looks at Plant Extracts.

There was good tolerance during the study as regards the following: adverse effects, the effects on blood pressure and heart rate, blood count, Quick's test, clinical chemistry as well as testosterone, FSH and LH values.

Who Took Part

According to the abstract, 20 subjects were involved.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

In design terms this was a placebo-controlled study.

A placebo (an inactive look-alike) gave the Plant Extracts group a baseline to be compared against.

During each study phase the 24-hour prolactin secretion profile was measured from the penultimate to the final day, and the amount of prolactin release was monitored an hour after TRH stimulation on the last day.

What Was Measured

There was good tolerance during the study as regards the following: adverse effects, the effects on blood pressure and heart rate, blood count, Quick's test, clinical chemistry as well as testosterone, FSH and LH values.

PubMed files the paper under topics including Plant Extracts, Prolactin and Thyrotropin-Releasing Hormone.

What This Means in Plain Language

The paper is a placebo-controlled study of Plant Extracts in 20 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1996 (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association), a journal based in Germany.

More context: all human trials.