Effects of ovine corticotropin-releasing hormone injection and desmopressin coadministration on galanin and adrenocorticotropin plasma levels in normal women

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

In the human pituitary, GAL is almost exclusively located within corticotrophs.

The researchers examined whether GAL is secreted from corticotrophs in response to stimuli that induce ACTH release.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Plasma levels of GAL and ACTH were evaluated in six healthy female subjects in the follicular phase of the menstrual cycle after the following treatments: 1) ovine CRH (oCRH) injection during saline (SAL) infusion, 2) oCRH injection during infusion of the arginine vasopressin analog desmopressin (DP), 3) SAL injection during DP infusion, and 4) SAL injection during SAL infusion.

How the Study Was Run

In design terms this was a randomized and single-blind study.

Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the participants, was kept unaware of whether ACTH (Corticotropin) was given.

What Was Measured

The subject headings attached to it are Adrenocorticotropic Hormone, Area Under Curve, Corticotropin-Releasing Hormone, Deamino Arginine Vasopressin, Drug Combinations, Galanin and Injections.

What This Means in Plain Language

The paper is a randomized and single-blind study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

The publication is from 1997 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.