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Urinary endothelin-1 excretion is enhanced by low-dose infusion of brain natriuretic peptide in normal humans
Plain-language guide to PMID 9039083 (1997): single-blind controlled clinical trial of BNP (Nesiritide) and Endothelin-1.
Key Facts
- PMID
- 9039083
- Journal
- Hypertension (Dallas, Tex. : 1979)
- Year
- 1997
- Study type
- Controlled Clinical Trial
- Authors
- De Feo ML et al. (7 authors)
- DOI
- 10.1161/01.hyp.29.1.70
What This Study Did, in Plain Language
What Was Tested
This controlled clinical trial looks at BNP (Nesiritide) and Endothelin-1.
Blood samples were drawn at intervals for measurement of hematocrit and concentrations of creatinine, electrolytes, brain natriuretic peptide, and endothelin-1.
Urine was collected an intervals for measurement of flow rate and concentrations of creatinine, sodium, cGMP, and endothelin-1.
Who Took Part
The age groups tagged for this paper are adults, both men and women.
How the Study Was Run
The researchers set it up as a single-blind, placebo-controlled and crossover study.
In this single-blind BNP (Nesiritide) study one party knew the assignments and the other did not.
A placebo (an inactive look-alike) gave the BNP (Nesiritide) group a baseline to be compared against.
Each person switched between BNP (Nesiritide) and the comparison at some point, usually with a gap in between.
Blood pressure and heart rate were measured every 15 minutes.
What Was Measured
Blood samples were drawn at intervals for measurement of hematocrit and concentrations of creatinine, electrolytes, brain natriuretic peptide, and endothelin-1.
Urine was collected an intervals for measurement of flow rate and concentrations of creatinine, sodium, cGMP, and endothelin-1.
The subject headings attached to it are Blood Proteins, Creatinine, Cyclic GMP, Endothelin-1, Kidney, Natriuretic Peptide, Brain and Nerve Tissue Proteins.
What This Means in Plain Language
The paper is a single-blind, placebo-controlled and crossover study of BNP (Nesiritide) and Endothelin-1.
The publication is from 1997 (Hypertension (Dallas, Tex. : 1979)), a journal based in United States.
More context: the BNP (Nesiritide) compound page and the Endothelin-1 compound page, all human trials.
Our Notes on the Compounds
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Endothelin-1: A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.