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Growth promotion and Turner-specific bone age after therapy with growth hormone and in combination with oxandrolone: when should therapy be started in Turner syndrome?

Plain-language guide to PMID 9050948 (1997): multicenter controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 67 girls.

Key Facts

PMID
9050948
Journal
Hormone research
Year
1997
Study type
Controlled Clinical Trial
Authors
Joss EE et al. (5 authors)
DOI
10.1159/000185443

What This Study Did, in Plain Language

What Was Tested

This controlled clinical trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The aims of this comparative multicenter study of 67 girls with Turner syndrome (TS) on three different therapeutical regimens were, first, to evaluate the effect of either recombinant human growth hormone (GH) alone or in combination with the anabolic steroid oxandrolone (Oxa) on height velocity and on Turner-specific bone age (BA'TS) and, second, to estimate the gain in final height taking the age at the onset of treatment into account.

Why It Was Studied

On all treatment regimens the advancement of BA'TS was more pronounced in the younger girls.

Who Took Part

According to the abstract, 67 girls were involved.

The age groups tagged for this paper are children, women only.

How the Study Was Run

In design terms this was a multicenter study.

Running at several centres spread the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study over different clinics and patient groups.

What Was Measured

The subject headings attached to it are Age Determination by Skeleton, Age Factors, Anabolic Agents, Body Height, Bone and Bones, Growth and Human Growth Hormone.

What This Means in Plain Language

The paper is a multicenter study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 67 girls.

The publication is from 1997 (Hormone research), a journal based in Switzerland.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.