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Growth hormone treatment of short children born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height.

Plain-language guide to PMID 9055904 (1996): clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 16 patients.

Key Facts

PMID
9055904
Journal
Acta paediatrica (Oslo, Norway : 1992). Supplement
Year
1996
Study type
Clinical Trial
Authors
Ranke MB et al. (2 authors)
DOI
10.1111/j.1651-2227.1996.tb14288.x

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a clinical trial.

For the SGA patients, median birth weight was -2.6 SD scores (SDS), treatment was started at a median age of 9.2 years, at a time when median height was -2.8 SDS while median target height was -1.4 SDS.

For the SRS patients, median birth weight was -3.1 SDS, treatment was started at a median age of 7.0 years, at a time when median height was -3.4 SDS with a median target height of -0.1 SDS.

Who Took Part

The abstract describes 16 patients taking part.

The age groups tagged for this paper are young children, children and teenagers, both men and women.

What Was Measured

For the SGA patients, median birth weight was -2.6 SD scores (SDS), treatment was started at a median age of 9.2 years, at a time when median height was -2.8 SDS while median target height was -1.4 SDS.

PubMed files the paper under topics including Abnormalities, Multiple, Birth Weight, Body Height, Dwarfism, Human Growth Hormone, Infant, Small for Gestational Age and Recombinant Proteins.

What This Means in Plain Language

This is a clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 16 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1996 (Acta paediatrica (Oslo, Norway : 1992). Supplement), a journal based in Norway.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.