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Failure of plasma atrial natriuretic peptide levels to increase during exercise in patients with chronic atrial fibrillation
Plain-language guide to PMID 9121953 (1997): single-blind and crossover controlled clinical trial study of ANP (Atrial Natriuretic Peptide) in 12 patients.
Key Facts
- PMID
- 9121953
- Journal
- Pacing and clinical electrophysiology : PACE
- Year
- 1997
- Study type
- Controlled Clinical Trial
- Authors
- Kelly PA et al. (6 authors)
- DOI
- 10.1111/j.1540-8159.1997.tb04806.x
What This Study Did, in Plain Language
What Was Tested
This controlled clinical trial paper looks at ANP (Atrial Natriuretic Peptide).
The aim of the study was to determine the importance of coordinated AC upon peripheral atrial natriuretic peptide levels (alpha-hANP) during exercise.
Why It Was Studied
It is generally accepted that plasma atrial natriuretic peptide release occurs secondary to atrial stretch.
The influence of coordinated atrial contraction (AC) upon this process is not fully appreciated.
Who Took Part
According to the abstract, 12 patients were involved.
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
Peripheral alpha-hANP levels were measured at rest and during exercise in 12 patients with complete heart block (CHB) and permanent rate responsive pacemakers.
How the Study Was Run
In design terms this was a single-blind and crossover study.
Only one side, usually the patients, was kept unaware of whether ANP (Atrial Natriuretic Peptide) was given.
Each person switched between ANP (Atrial Natriuretic Peptide) and the comparison at some point, usually with a gap in between.
What Was Measured
It is generally accepted that plasma atrial natriuretic peptide release occurs secondary to atrial stretch.
Each patient performed three treadmill exercise tests.
PubMed files the paper under topics including Atrial Fibrillation, Atrial Natriuretic Factor, Cardiac Pacing, Artificial, Chronic Disease, Echocardiography, Electrocardiography and Exercise Test.
What This Means in Plain Language
The paper is a single-blind and crossover study of ANP (Atrial Natriuretic Peptide) in 12 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1997 (Pacing and clinical electrophysiology : PACE), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.