Evidence for central nervous effects of corticotropin-releasing hormone on gastric acid secretion in humans

What Was Tested

Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this randomized controlled trial publication.

Evidence exists that in man peptides have a direct access to the brain upon intranasal administration.

This study aimed at assessing brain-mediated effects of CRH on gastric pH after intranasal administration in humans.

Who Took Part

The age groups tagged for this paper are teenagers and adults, men only.

The subject's mood was assessed by an adjective list (EWL-N) at the end of each experimental condition.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

The participants were allocated by chance, so the ACTH (Corticotropin) group and the comparison group should start out alike.

As a double-blind ACTH (Corticotropin) study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the ACTH (Corticotropin) group a baseline to be compared against.

Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.

Gastric pH values were measured continuously by a gastral pH tube.

What Was Measured

This study aimed at assessing brain-mediated effects of CRH on gastric pH after intranasal administration in humans.

The subject headings attached to it are Central Nervous System, Corticotropin-Releasing Hormone, Gastric Acid, Hydrogen-Ion Concentration and Stomach.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

The publication is from 1997 (Neuroendocrinology), a journal based in Switzerland.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.