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Subacute infusion of physiological doses of parathyroid hormone raises blood pressure in humans
Plain-language guide to PMID 9175045 (1997): double-blind randomized controlled trial study of Teriparatide and Parathyroid Hormone (PTH 1-84) in 10 subjects, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 9175045
- Journal
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Fliser D et al. (7 authors)
- DOI
- 10.1093/ndt/12.5.933
What This Study Did, in Plain Language
What Was Tested
Researchers studied Teriparatide and Parathyroid Hormone (PTH 1-84) in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.
This effect contrasts with the putative role of secondary hyperparathyroidism in the pathogenesis of hypertension of patients with renal failure.
Uraemia is characterized by insulin resistance and hyperinsulinaemia.
Who Took Part
According to the abstract, 10 subjects were involved.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized, double-blind and crossover.
Random assignment meant chance, not the researchers, decided who got Teriparatide and who got the comparison, which limits bias.
Blinding on both sides kept the subjects and researchers unaware of who received Teriparatide.
In the crossover set-up each of the subjects took both Teriparatide and the comparison in turn, acting as their own control.
What Was Measured
This effect contrasts with the putative role of secondary hyperparathyroidism in the pathogenesis of hypertension of patients with renal failure.
Topics PubMed links to this paper include Blood Glucose, Blood Platelets, Blood Pressure, Calcium, Hypertension, Insulin and Insulin Resistance.
What This Means in Plain Language
The paper is a randomized, double-blind and crossover study of Teriparatide and Parathyroid Hormone (PTH 1-84) in 10 subjects in people with low blood pressure and orthostatic hypotension.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1997 (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association), a journal based in England.
More context: the Teriparatide compound page and the Parathyroid Hormone (PTH 1-84) compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compounds
Teriparatide: A parathyroid hormone fragment, PTH(1-34), with human trials and approved-pen labeling; the research vial is not the approved pen.
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Teriparatide in the library
- Parathyroid Hormone (PTH 1-84) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.