Serum leptin is increased in growth hormone-deficient adults: relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year.

Plain-language guide to PMID 9225837 (1997): double-blind controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 42 adults.

Key Facts

PMID: 9225837
Journal: Metabolism: clinical and experimental
Year: 1997
Study type: Controlled Clinical Trial
Authors: Fisker S et al. (7 authors)
DOI: 10.1016/s0026-0495(97)90128-1

What This Study Did, in Plain Language

What Was Tested

This controlled clinical trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The gene product from the ob gene, leptin, has recently been characterized in humans.

The circulating level of leptin is related to body mass index (BMI) and more closely to estimates of total body fat, whereas visceral fat has been reported to be of minor importance.

Who Took Part

The study group was 42 adults.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a double-blind, placebo-controlled and parallel-group study.

Neither the adults nor the staff measuring them knew who was on Exogenous HGH, sermorelin & older GHRPs (why they're passed over), so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group a baseline to be compared against.

Groups ran in parallel: each of the adults stayed in one arm throughout.

What Was Measured

The circulating level of leptin is related to body mass index (BMI) and more closely to estimates of total body fat, whereas visceral fat has been reported to be of minor importance.

The same measurements were performed in 42 healthy adults aged 39.1 +/- 1.7 years.

Topics PubMed links to this paper include Absorptiometry, Photon, Adipose Tissue, Body Composition, Body Constitution, Electric Impedance, Human Growth Hormone and Leptin.

What This Means in Plain Language

The paper is a double-blind, placebo-controlled and parallel-group study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 42 adults.

The publication is from 1997 (Metabolism: clinical and experimental), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.