Olestra's effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins.

What Was Tested

This randomized controlled trial looks at Vitamin D.

The primary purpose of the study was to determine the amounts of vitamins D and E needed to offset the effect of olestra on the availability of these vitamins.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and parallel-group.

Random assignment meant chance, not the researchers, decided who got Vitamin D and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Vitamin D, so expectations could not easily colour the readings.

The Vitamin D group and the comparison group ran side by side rather than switching.

Serum concentrations of retinol, carotenoids, 25-hydroxyvitamin D metabolites, alpha-tocopherol, phylloquinone, lipids, ferritin and total iron, iron-binding capacity and hematology parameters, plasma concentrations of des-gamma-carboxyprothrombin and prothrombin, and urinary gamma-carboxyglutamic acid (Gla) excretion were measured biweekly.

Clinical chemistry and urinalysis parameters, vitamin B12 absorption, and serum 1,25-dihydroxyvitamin D concentration were measured at wk 0 and 8.

What Was Measured

PubMed files the paper under topics including 25-Hydroxyvitamin D 2, Calcifediol, Diarrhea, Dietary Fats, Unsaturated, Fat Substitutes, Fatty Acids and Iron.

What This Means in Plain Language

The paper is a randomized, double-blind and parallel-group study of Vitamin D.

The publication is from 1997 (The Journal of nutrition), a journal based in United States.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.