← Human Trials & Peer-Reviewed Studies
Nafarelin vs. leuprolide acetate depot for endometriosis. Changes in bone mineral density and vasomotor symptoms. Nafarelin Study Group
Plain-language guide to PMID 9252932 (1997): double-blind randomized controlled trial study of Leuprolide and Nafarelin in 99 subjects, endometriosis.
Key Facts
- PMID
- 9252932
- Journal
- The Journal of reproductive medicine
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Agarwal SK et al. (4 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Leuprolide and Nafarelin in the context of endometriosis, published as a randomized controlled trial.
To compare intranasal nafarelin and intramuscular leuprolide acetate (LA) depot in the management of endometriosis.
Who Took Part
According to the abstract, 99 subjects were involved.
The age groups tagged for this paper are adults, women only.
A multicenter, prospective, randomized, double-placebo, double-blind study was conducted on subjects who had symptoms and signs of endometriosis and bone mineral density (BMD) within the age-appropriate normal range.
Subjects were followed throughout treatment and for six months after treatment.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and multicenter study.
The subjects were allocated by chance, so the Leuprolide group and the comparison group should start out alike.
Blinding on both sides kept the subjects and researchers unaware of who received Leuprolide.
The comparison arm used a placebo, so changes seen with Leuprolide could be set against what happens without it.
More than one site took part, so the subjects came from several places.
The timeline in the abstract includes six months.
The main outcome measures were changes in endometriosis symptoms and signs, BMD measurements, subject-reported and objectively measured hot flushes and circulating estradiol concentrations.
What Was Measured
The subject headings attached to it are Bone Density, Endometriosis, Estradiol, Leuprolide, Nafarelin, Ovary and Vasomotor System.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Leuprolide and Nafarelin in 99 subjects in people with endometriosis over six months.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 1997 (The Journal of reproductive medicine), a journal based in United States.
More context: the Leuprolide compound page and the Nafarelin compound page, Endometriosis research.
Our Notes on the Compounds
Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.
Nafarelin: A GnRH analog nasal spray (Synarel) used in endometriosis and early puberty.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.