Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis

Plain-language guide to PMID 9284777 (1997): randomized controlled trial study of Teriparatide and Parathyroid Hormone (PTH 1-84), osteoporosis and bone density.

Key Facts

PMID: 9284777
Journal: Lancet (London, England)
Year: 1997
Study type: Randomized Controlled Trial
Authors: Lindsay R et al. (8 authors)
DOI: 10.1016/S0140-6736(97)02342-8

What This Study Did, in Plain Language

What Was Tested

Researchers studied Teriparatide and Parathyroid Hormone (PTH 1-84) in the context of osteoporosis and bone density in this randomized controlled trial publication.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, women only.

The controls were women taking hormone-replacement therapy only (n = 17).

How the Study Was Run

The design is described as randomized.

Because people in this Teriparatide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The primary outcome was bone-mineral density of the lumbar vertebrae, with bone-mineral density at other sites and vertebral fractures as secondary endpoints.

What Was Measured

PubMed files the paper under topics including Absorptiometry, Photon, Biomarkers, Bone Density, Estrogen Replacement Therapy, Estrogens, Fractures, Bone and Incidence.

What This Means in Plain Language

The paper is a randomized study of Teriparatide and Parathyroid Hormone (PTH 1-84) in people with osteoporosis and bone density.

Results are reported in around 12 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1997 (Lancet (London, England)), a journal based in England.

More context: the Teriparatide compound page and the Parathyroid Hormone (PTH 1-84) compound page, Osteoporosis and bone density research.

Our Notes on the Compounds

Teriparatide: A parathyroid hormone fragment, PTH(1-34), with human trials and approved-pen labeling; the research vial is not the approved pen.

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.