← Human Trials & Peer-Reviewed Studies
Effect of antenatal thyrotropin-releasing hormone on uterine contractility, blood pressure, and maternal heart rate
Plain-language guide to PMID 9290464 (1997): double-blind randomized controlled trial study of TRH (Thyrotropin-Releasing Hormone) in 30 women, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 9290464
- Journal
- American journal of obstetrics and gynecology
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Devlieger R et al. (5 authors)
- DOI
- 10.1016/s0002-9378(97)70211-4
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at TRH (Thyrotropin-Releasing Hormone) in the context of low blood pressure and orthostatic hypotension.
The goal was to study the effects on uterine contractility, blood pressure, and heart rate of thyrotropin-releasing hormone given antenatally in combination with glucocorticoids to accelerate fetal maturation.
Who Took Part
The abstract describes 30 women taking part.
PubMed tags the participants as women only.
A placebo-controlled, randomized, double-blind study was performed involving 30 women whose pregnancies were followed up at the University Hospital Gasthuisberg in 1994 and 1995.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got TRH (Thyrotropin-Releasing Hormone) and who got the comparison, which limits bias.
Blinding on both sides kept the women and researchers unaware of who received TRH (Thyrotropin-Releasing Hormone).
The comparison arm used a placebo, so changes seen with TRH (Thyrotropin-Releasing Hormone) could be set against what happens without it.
What Was Measured
The subject headings attached to it are Blood Pressure, Heart Rate, Thyrotropin-Releasing Hormone and Uterine Contraction.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of TRH (Thyrotropin-Releasing Hormone) in 30 women in people with low blood pressure and orthostatic hypotension.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1997 (American journal of obstetrics and gynecology), a journal based in United States.
More context: the TRH (Thyrotropin-Releasing Hormone) compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
TRH (Thyrotropin-Releasing Hormone): A 3-amino-acid hypothalamic hormone (protirelin) that triggers TSH and prolactin release.
Related Pages
- Low blood pressure and orthostatic hypotension research
- TRH (Thyrotropin-Releasing Hormone) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.