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The effects of pathophysiological increments in brain natriuretic peptide in left ventricular systolic dysfunction
Plain-language guide to PMID 9314423 (1997): single-blind randomized controlled trial study of BNP (Nesiritide) in 4 patients.
Key Facts
- PMID
- 9314423
- Journal
- Hypertension (Dallas, Tex. : 1979)
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Lainchbury JG et al. (8 authors)
- DOI
- 10.1161/01.hyp.30.3.398
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.
Plasma levels of brain natriuretic peptide (BNP) are raised in patients with left ventricular impairment and may play a role in the adaptation to left ventricular impairment.
Manipulation of BNP levels may have therapeutic potential.
Who Took Part
The abstract describes 4 patients taking part.
The age groups tagged for this paper are middle-aged adults and older adults, men only.
How the Study Was Run
The design is described as randomized, single-blind, placebo-controlled and crossover.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Only one side, usually the patients, was kept unaware of whether BNP (Nesiritide) was given.
The comparison arm used a placebo, so changes seen with BNP (Nesiritide) could be set against what happens without it.
In the crossover set-up each of the patients took both BNP (Nesiritide) and the comparison in turn, acting as their own control.
Endocrine, renal, and hemodynamic effects were measured.
What Was Measured
Plasma levels of brain natriuretic peptide (BNP) are raised in patients with left ventricular impairment and may play a role in the adaptation to left ventricular impairment.
Manipulation of BNP levels may have therapeutic potential.
The subject headings attached to it are Echocardiography, Hemodynamics, Hormones, Kidney, Natriuretic Peptide, Brain, Nerve Tissue Proteins and Systole.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of BNP (Nesiritide) in 4 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1997 (Hypertension (Dallas, Tex. : 1979)), a journal based in United States.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.