Magnetic resonance images of 91 children with different causes of short stature: pituitary size reflects growth hormone secretion.

What It Covers

This review looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

In order to validate an association between pituitary size and severity of growth hormone deficiency (GHD) the researchers evaluated the magnetic resonance images (MRI) of 107 children with different causes of short stature.

Ninety-one MRIs were evaluable (64 male, 27 female; age: 9.1 +/- 3.9 years).

Who the Included Studies Covered

The age groups tagged for this paper are children and teenagers, both men and women.

How the Review Was Done

Pituitary height (PHT) was measured and hypoplasia was assumed when PHT was < -2 SDS.

What Was Measured

In order to validate an association between pituitary size and severity of growth hormone deficiency (GHD) the researchers evaluated the magnetic resonance images (MRI) of 107 children with different causes of short stature.

The levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), and tests of GH stimulation and spontaneous secretion, led to the following subgroups: severe isolated GHD (SIGHD) (GH < 7 ng/ml) (n = 21); partial, isolated GHD (GH 7-10 ng/ml) (n = 22); multiple pituitary hormone deficiency (MPHD) (n = 13); neurosecretory dysfunction (n = 10); non-classifiable diagnosis (NC) (n = 13); idiopathic short stature (n = 9); and intra-uterine growth retardation (n = 3).

Topics PubMed links to this paper include Diagnosis, Differential, Dwarfism, Pituitary, Human Growth Hormone, Magnetic Resonance Imaging, Organ Size, Pituitary Function Tests and Pituitary Gland.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Results are reported in around 2 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1997 (European journal of pediatrics), a journal based in Germany.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.