Maternal colonization with group B Streptococcus and prelabor rupture of membranes at term: the role of induction of labor. TermPROM Study Group.

What Was Tested

This randomized controlled trial looks at Oxytocin.

Their purpose was to determine the effect of induction of labor on neonatal infection if mothers are group B streptococci positive and have prelabor rupture of membranes at term.

The researchers used logistic regression to test for effects of treatment within group B streptococci subgroups.

Who Took Part

The abstract describes 5041 women taking part.

PubMed tags the participants as women only.

In the TermPROM study 5041 women were randomized to induction with intravenous oxytocin, induction with vaginal prostaglandin E2 gel, or expectant management with induction, if needed.

Of these, 4834 women had vaginal or introital swabs for group B streptococci taken at entry.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Oxytocin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

PubMed files the paper under topics including Administration, Intravaginal, Dinoprostone, Premature Rupture of Fetal Membranes, Gestational Age, Infectious Disease Transmission, Vertical, Labor, Induced and Logistic Models.

What This Means in Plain Language

The paper is a randomized study of Oxytocin in 5041 women.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1997 (American journal of obstetrics and gynecology), a journal based in United States.

More context: the related Oxytocin library page, all human trials.