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Effects of endothelin-1 on circulating adhesion molecules in man
Plain-language guide to PMID 9373765 (1997): double-blind randomized controlled trial study of Endothelin-1.
Key Facts
- PMID
- 9373765
- Journal
- European journal of clinical investigation
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Jilma B et al. (8 authors)
- DOI
- 10.1046/j.1365-2362.1997.2080755.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Endothelin-1.
Several studies point to a role for endothelin-1 (ET-1) in enhancing adhesion molecule expression and leucocyte adhesion.
The researchers thus hypothesized that ET-1 would induce expression of adhesion molecules by endothelial cells and by leucocytes in humans, and hence compared with placebo the effect of a continuous 6-h ET-1 infusion on plasma levels of circulating (c)E-selectin, cP-selectin, intercellular and vascular cell adhesion molecule 1.
Who Took Part
The age groups tagged for this paper are adults, men only.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled, crossover and pilot study.
The participants were allocated by chance, so the Endothelin-1 group and the comparison group should start out alike.
As a double-blind Endothelin-1 study, the assignments were hidden from both participants and investigators until the end.
Some participants received a placebo instead of Endothelin-1, giving a reference point.
In the crossover set-up each of the participants took both Endothelin-1 and the comparison in turn, acting as their own control.
What Was Measured
The researchers thus hypothesized that ET-1 would induce expression of adhesion molecules by endothelial cells and by leucocytes in humans, and hence compared with placebo the effect of a continuous 6-h ET-1 infusion on plasma levels of circulating (c)E-selectin, cP-selectin, intercellular and vascular cell adhesion molecule 1.
The subject headings attached to it are CD11 Antigens, CD18 Antigens, Cell Adhesion Molecules, Endothelin-1, Hemodynamics, Intercellular Adhesion Molecule-1 and Pilot Projects.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Endothelin-1.
The publication is from 1997 (European journal of clinical investigation), a journal based in England.
More context: the Endothelin-1 compound page, all human trials.
Our Notes on the Compound
Endothelin-1: A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.