← Human Trials & Peer-Reviewed Studies
[Different ophthalmologic surgery irrigation solutions. Studies of postoperative inflammation].
Plain-language guide to PMID 9376698 (1997): double-blind randomized controlled trial of Bicarbonates.
Key Facts
- PMID
- 9376698
- Journal
- Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Stoldt G et al. (2 authors)
- DOI
- 10.1007/s003470050163
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Bicarbonates, published as a randomized controlled trial.
Three different solutions, "E153", a complete electrolyte solution for intravenous infusion, as well as Alcon BSS and Alcon BSS Plus, two balanced solutions developed for eye surgery, were tested with regard to their possible effects on postsurgical inflammation progress after cataract extraction.
Who Took Part
The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.
Seventy-four patients aged 40 to 85 years (39 female, 35 male) were included in a prospective randomized double-blind study.
The following served as criteria: Comparison of the pre- and postoperative flare values by means of measurements carried out with Laser-Flare-Meter Kowa FM 500 Clinical assessment by means of a score.
How the Study Was Run
The design is described as randomized and double-blind.
Random assignment meant chance, not the researchers, decided who got Bicarbonates and who got the comparison, which limits bias.
As a double-blind Bicarbonates study, the assignments were hidden from both participants and investigators until the end.
What Was Measured
Three different solutions, "E153", a complete electrolyte solution for intravenous infusion, as well as Alcon BSS and Alcon BSS Plus, two balanced solutions developed for eye surgery, were tested with regard to their possible effects on postsurgical inflammation progress after cataract extraction.
The subject headings attached to it are Bicarbonates, Drug Combinations, Endophthalmitis, Glutathione, Ophthalmic Solutions, Phacoemulsification and Postoperative Complications.
What This Means in Plain Language
The paper is a randomized and double-blind study of Bicarbonates.
Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1997 (Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft), a journal based in Germany.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.