Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

Brachial venoarterial plasma concentration gradients and forearm plasma flow were used to determine net release/uptake rates of t-PA and vWF.

Why It Was Studied

However, the mechanisms behind these responses are not known.

The researchers tested the hypothesis that DDAVP acts as a local stimulator of acute endothelial release of t-PA and vWF independently of central pathways.

Who Took Part

The study group was 4 subjects.

PubMed indexes the participants as adults, men only.

How the Study Was Run

In design terms this was a randomized, single-blind and placebo-controlled study.

The subjects were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

In this single-blind Vasopressin study one party knew the assignments and the other did not.

The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.

What Was Measured

The researchers tested the hypothesis that DDAVP acts as a local stimulator of acute endothelial release of t-PA and vWF independently of central pathways.

Topics PubMed links to this paper include Blood Pressure, Deamino Arginine Vasopressin, Forearm, Regional Blood Flow and Tissue Plasminogen Activator.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Vasopressin and Desmopressin in 4 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1998 (Blood), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.