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Venous ulcers: improved healing by iontophoretic administration of calcitonin gene-related peptide and vasoactive intestinal polypeptide
Plain-language guide to PMID 9427920 (1998): randomized controlled trial of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide) in 66 patients.
Key Facts
- PMID
- 9427920
- Journal
- Plastic and reconstructive surgery
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Gherardini G et al. (8 authors)
- DOI
- 10.1097/00006534-199801000-00015
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide), published as a randomized controlled trial.
A study on the effects of iontophoretic administration of calcitonin gene-related peptide and vasoactive intestinal polypeptide on the healing of venous stasis ulcers of the extremities was carried out on 66 patients.
Two randomized groups of patients were compared, one receiving standard treatment plus iontophoresis of calcitonin gene-related peptide and vasoactive intestinal polypeptide, and the other receiving standard treatment plus placebo iontophoresis.
Who Took Part
According to the abstract, 66 patients were involved.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got VIP (Vasoactive Intestinal Peptide) and who got the comparison, which limits bias.
Some patients received a placebo instead of VIP (Vasoactive Intestinal Peptide), giving a reference point.
What Was Measured
A study on the effects of iontophoretic administration of calcitonin gene-related peptide and vasoactive intestinal polypeptide on the healing of venous stasis ulcers of the extremities was carried out on 66 patients.
Two randomized groups of patients were compared, one receiving standard treatment plus iontophoresis of calcitonin gene-related peptide and vasoactive intestinal polypeptide, and the other receiving standard treatment plus placebo iontophoresis.
Topics PubMed links to this paper include Calcitonin Gene-Related Peptide, Iontophoresis, Varicose Ulcer and Vasoactive Intestinal Peptide.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide) in 66 patients.
The publication is from 1998 (Plastic and reconstructive surgery), a journal based in United States.
More context: the VIP (Vasoactive Intestinal Peptide) compound page and the CGRP (Calcitonin Gene-Related Peptide) compound page, all human trials.
Our Notes on the Compounds
VIP (Vasoactive Intestinal Peptide): A 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune activity; aviptadil is a synthetic form.
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
- VIP (Vasoactive Intestinal Peptide) in the library
- CGRP (Calcitonin Gene-Related Peptide) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.