Sensory changes and pain after abdominal hysterectomy: a comparison of anesthetic supplementation with fentanyl versus magnesium or ketamine.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Drugs interacting with opioid or N-methyl-D-aspartate (NMDA) receptors may have differing effects on post-surgical sensory changes, such as central inhibition or spinal excitation.

The researchers compared the effect of supplementing isoflurane/N2O/O2 anesthesia with an opioid agonist (fentanyl [n = 15]) or two drugs inhibiting the NMDA system differently (magnesium, ketamine [n = 15 in each group]) on sensory changes after abdominal hysterectomy.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, women only.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

What Was Measured

Electric sensation, pain detection, and pain tolerance thresholds were determined (preoperatively and 1, 4, 24 h, and 5 days postoperatively) in arm, thoracic, incision, and leg dermatomes together with pain scores and cumulative morphine consumption.

Pain scores and morphine consumption were similar.

PubMed files the paper under topics including Analgesics, Opioid, Fentanyl, Hysterectomy, Ketamine, Magnesium, Pain Threshold and Receptors, N-Methyl-D-Aspartate.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (Anesthesia and analgesia), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.