Gender affects renal vasoconstrictor response to Ang I and Ang II.

What Was Tested

This randomized controlled trial looks at Angiotensin I.

This study tested the hypothesis that gender affects the pressor and renal vasoconstrictor responses to angiotensin (Ang) I and Ang II in salt-replete normotensive subjects.

Although pressor responses to Ang I and Ang II were similar in men and women, there was a negative relationship between the change in mean arterial pressure and the change in heart rate during Ang I and II infusion in women only.

Who Took Part

The study group was 9 men.

PubMed indexes the participants as adults, both men and women.

How the Study Was Run

In design terms this was a randomized, single-blind and crossover study.

Random assignment meant chance, not the researchers, decided who got Angiotensin I and who got the comparison, which limits bias.

In this single-blind Angiotensin I study one party knew the assignments and the other did not.

In the crossover set-up each of the men took both Angiotensin I and the comparison in turn, acting as their own control.

What Was Measured

This study tested the hypothesis that gender affects the pressor and renal vasoconstrictor responses to angiotensin (Ang) I and Ang II in salt-replete normotensive subjects.

Topics PubMed links to this paper include Aldosterone, Analysis of Variance, Angiotensin I, Angiotensin II, Blood Pressure, Heart Rate and Renal Circulation.

What This Means in Plain Language

The paper is a randomized, single-blind and crossover study of Angiotensin I in 9 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1998 (Hypertension (Dallas, Tex. : 1979)), a journal based in United States.

More context: all human trials.