Timed unilateral ovarian follicular aspiration prior to administration of human chorionic gonadotrophin for the prevention of severe ovarian hyperstimulation syndrome in in-vitro fertilization: a prospective randomized study.

What Was Tested

Researchers studied Chorionic Gonadotropin in this randomized controlled trial publication.

Unilateral ovarian follicular aspiration 6-8 h prior to trigger administration of human chorionic gonadotrophin (HCG) was performed or not in 31 women at serious risk of ovarian hyperstimulation syndrome (OHSS) after ovarian stimulation for in-vitro fertilization (IVF)-embryo transfer or intracytoplasmic sperm injection (ICSI) in this prospective randomized study.

Unilateral follicular aspiration was performed in 16 women (group 1) matched for age, indication for fertility treatment, and the amount and duration of gonadotrophin exposure with 15 women not receiving aspiration treatment (group 2).

Who Took Part

The study group was 31 women.

By PubMed's age tags, the people studied were adults, women only.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Chorionic Gonadotropin and who got the comparison, which limits bias.

What Was Measured

Topics PubMed links to this paper include Chorionic Gonadotropin, Estradiol, Fertilization in Vitro, Menotropins, Ovarian Follicle, Ovarian Hyperstimulation Syndrome and Suction.

What This Means in Plain Language

The paper is a randomized study of Chorionic Gonadotropin in 31 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1997 (Human reproduction (Oxford, England)), a journal based in England.

More context: the related hCG (human chorionic gonadotropin) library page, all human trials.