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Pharmacokinetics and pharmacodynamics of recombinant human growth hormone by subcutaneous jet- or needle-injection in patients with growth hormone deficiency.
Plain-language guide to PMID 9475305 (1997): crossover randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 9475305
- Journal
- Acta paediatrica (Oslo, Norway : 1992)
- Year
- 1997
- Study type
- Randomized Controlled Trial
- Authors
- Houdijk EC et al. (3 authors)
- DOI
- 10.1111/j.1651-2227.1997.tb14902.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.
Plasma growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), glucose, insulin, HbAlc and serum-free fatty acids (FFA) levels were analysed repeatedly.
GH absorption characteristics, expressed as AUC(0-infinity), Cmax and Tmax ratio (%) jet-injected over needle-injected were similar in both groups.
Who Took Part
By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.
How the Study Was Run
In design terms this was a randomized and crossover study.
Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.
What Was Measured
Plasma growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), glucose, insulin, HbAlc and serum-free fatty acids (FFA) levels were analysed repeatedly.
IGF-I and IGFBP-3 plasma levels were identical in both groups.
Topics PubMed links to this paper include Absorption, Analysis of Variance, Biological Availability, Blood Glucose, Confidence Intervals, Glycated Hemoglobin and Growth Disorders.
What This Means in Plain Language
The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The publication is from 1997 (Acta paediatrica (Oslo, Norway : 1992)), a journal based in Norway.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.