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Zinc supplementation: effects on the growth and morbidity of undernourished Jamaican children.
Plain-language guide to PMID 9481530 (1998): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 9481530
- Journal
- European journal of clinical nutrition
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Meeks Gardner J et al. (3 authors)
- DOI
- 10.1038/sj.ejcn.1600509
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The researchers investigated whether there was a growth or morbidity response to zinc supplementation.
Who Took Part
PubMed indexes the participants as infants, both men and women.
Children were recruited at clinics in Kingston, Jamaica, and supplemented at home.
Children selected were singletons aged 6-24 months, and stunted (< -2.0 s.d. length for age, NCHS references).
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
The study was randomized, placebo-controlled, and double-blind.
They were stratified by sex and age and randomly assigned to receive zinc supplement (n = 31) or placebo (n = 30).
Four children were excluded because of hospitalization; all others had all measurements.
Adequately nourished children (n = 24) were recruited from a well-baby clinic.
What Was Measured
Topics PubMed links to this paper include Growth, Hair, Hospitalization, Jamaica, Morbidity, Nutrition Disorders and Zinc.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 10 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1998 (European journal of clinical nutrition), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.