Nasal absorption of hydroxocobalamin in healthy elderly adults

What Was Tested

The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.

To investigate the nasal absorption of hydroxocobalamin in 10 healthy elderly adults.

Who Took Part

The abstract describes 10 adults taking part.

By PubMed's age tags, the people studied were older adults, both men and women.

How the Study Was Run

The design is described as randomized and crossover.

Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the adults took both Cyanocobalamin (Vitamin B12) and the comparison in turn, acting as their own control.

In a cross-over study, blood samples were collected before administration of the drug and after 10, 20, 30, 40, 60, 120, 180 and 240 min.

The plasma cobalamin concentration was determined by competitive radioisotope binding technique.

What Was Measured

Topics PubMed links to this paper include Absorption, Administration, Inhalation, Hematinics, Hydroxocobalamin and Nasal Mucosa.

What This Means in Plain Language

The paper is a randomized and crossover study of Cyanocobalamin (Vitamin B12) in 10 adults.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (British journal of clinical pharmacology), a journal based in England.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.