Histamine release from bronchoalveolar lavage cells from asthmatic subjects after allergen challenge and relationship to the late asthmatic response.

What Was Tested

This clinical trial looks at Substance P.

The late asthmatic response provides a useful model of clinical asthma.

The aim of the study was to examine metachromatic cell derived mediators and histamine releasability in vitro after in vivo allergen exposure in atopic subjects with and without asthma and relate them to the type of physiological response observed.

Why It Was Studied

Their ability to synthesize and store proinflammatory cytokines has focused renewed interest on their role in asthma.

Who Took Part

The age groups tagged for this paper are teenagers and adults, both men and women.

How the Study Was Run

Bronchoalveolar lavage (BAL) cells were obtained 4 h after challenge from asthmatics exhibiting a single early response (EAR, n = 5), a dual response (LAR, n = 7), unchallenged (basal, n = 5), atopic non-asthmatic (ANA, n = 6) and non-atopic non-asthmatics (normal, n = 5).

BAL histamine and tryptase concentrations and in vitro histamine release (HR) after stimulation with anti-IgE, allergen, A23187, conconavalin A and substance P were compared.

What Was Measured

PubMed files the paper under topics including Allergens, Antibodies, Anti-Idiotypic, Asthma, Basophils, Bronchial Provocation Tests, Bronchoalveolar Lavage Fluid and Chymases.

What This Means in Plain Language

This is a clinical trial of Substance P.

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology), a journal based in England.

More context: the related Substance P library page, all human trials.