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Influence of angiotensin converting enzyme inhibition and angiotensin II type 1 receptor antagonism on renal sodium and water handling and albuminuria during infusion of atrial natriuretic factor into healthy volunteers
Plain-language guide to PMID 9535153 (1998): double-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 9535153
- Journal
- Journal of hypertension
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Vervoort G et al. (4 authors)
- DOI
- 10.1097/00004872-199816020-00016
What This Study Did, in Plain Language
What Was Tested
Researchers studied ANP (Atrial Natriuretic Peptide) in this randomized controlled trial publication.
To test the hypothesis that atrial natriuretic factor mediates natriuresis and diuresis by inhibiting angiotensin II, by studying the effects of the angiotensin converting enzyme inhibitor enalapril and the angiotensin II type 1 receptor antagonist losartan.
In addition, the effects of these drugs on atrial natriuretic factor-induced albuminuria were examined.
Who Took Part
PubMed indexes the participants as adults.
The researchers investigated the effects of enalapril and losartan on atrial natriuretic factor-induced changes in urinary excretion of sodium, water and albumin from eight healthy volunteers.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received ANP (Atrial Natriuretic Peptide).
Some participants received a placebo instead of ANP (Atrial Natriuretic Peptide), giving a reference point.
What Was Measured
PubMed files the paper under topics including Albuminuria, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Atrial Natriuretic Factor, Blood Pressure, Diuresis and Enalapril.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide).
Results are reported in around 11 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1998 (Journal of hypertension), a journal based in Netherlands.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.