Effects of triptorelin versus placebo on the symptoms of endometriosis

What Was Tested

This randomized controlled trial paper looks at Triptorelin in the context of endometriosis.

To compare the effect of a GnRH-agonist, triptorelin, versus placebo on the symptoms of endometriosis.

Who Took Part

PubMed indexes the participants as adults, women only.

A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.

Departments of Obstetrics and Gynecology at two universities and one general hospital.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Triptorelin group and the comparison group should start out alike.

As a double-blind Triptorelin study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Triptorelin could be set against what happens without it.

The timeline in the abstract includes 12 months.

Forty-nine women with symptoms of laparoscopically verified endometriosis.

Triptorelin depot or placebo was given every 4 weeks.

Clinical evaluation, including the Duration Intensity Behavior Scale and Visual Analogue Scale for pain, was performed before the injections and up to 12 months after treatment.

A control laparoscopy was performed 4-6 weeks after the last injection.

What Was Measured

The subject headings attached to it are Endometriosis, Luteolytic Agents, Pain Measurement, Patient Dropouts, Pelvic Pain and Triptorelin Pamoate.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Triptorelin in people with endometriosis over 12 months.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (Fertility and sterility), a journal based in United States.

More context: the Triptorelin compound page, Endometriosis research.