A comparative study of pharmacodynamics and bioavailability of 2 different desmopressin nasal sprays

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

Urine osmolalities, analyzed as area under the time curve (AUCosm) and maximum urine osmolalities were similar for both nasal sprays.

Urine volume, analyzed as area under the time curve, was raised after treatment with the test preparation.

Who Took Part

PubMed indexes the participants as adults, men only.

How the Study Was Run

The design is described as randomized, crossover and parallel-group.

The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

In the crossover set-up each of the participants took both Vasopressin and the comparison in turn, acting as their own control.

Groups ran in parallel: each of the participants stayed in one arm throughout.

The antidiuretic activity was measured by determination of urine osmolality and diuresis every 15 minutes over a period of 8 hours.

What Was Measured

Urine volume, analyzed as area under the time curve, was raised after treatment with the test preparation.

Plasma levels of desmopressin, measured by a specific and sensitive radio-immunoassay method, were already detectable 20 minutes after administration.

PubMed files the paper under topics including Area Under Curve, Biological Availability, Confidence Intervals, Deamino Arginine Vasopressin, Diuresis, Osmolar Concentration and Radioimmunoassay.

What This Means in Plain Language

The paper is a randomized, crossover and parallel-group study of Vasopressin and Desmopressin.

The publication is from 1998 (International journal of clinical pharmacology and therapeutics), a journal based in Germany.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.