GH dependence and GH withdrawal syndrome in GH treatment of short normal children: evidence from growth and cardiac output.

What Was Tested

Researchers studied Human Growth Hormone in this randomized controlled trial publication.

Yet, after discontinuation of GH therapy, growth came close to a complete stand-still.

The present report focuses on describing the period beyond GH withdrawal and its impact on growth and cardiac performance.

Who Took Part

According to the abstract, 12 children were involved.

The age groups tagged for this paper are young children and children.

How the Study Was Run

The design is described as randomized.

The children were allocated by chance, so the Human Growth Hormone group and the comparison group should start out alike.

Growth and echocardiography were followed during therapy and 2 years thereafter.

What Was Measured

Growth rate remained low for the next year, and recovered to pretreatment velocity by the fourth semiannual measurement.

PubMed files the paper under topics including Body Height, Bone Development, Cardiac Output, Case-Control Studies, Echocardiography, Human Growth Hormone and Insulin-Like Growth Factor I.

What This Means in Plain Language

The paper is a randomized study of Human Growth Hormone in 12 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1998 (European journal of endocrinology), a journal based in England.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.