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Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting.
Plain-language guide to PMID 9605087 (1998): randomized controlled trial of Bicarbonates.
Key Facts
- PMID
- 9605087
- Journal
- The Journal of thoracic and cardiovascular surgery
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Shanewise JS et al. (4 authors)
- DOI
- 10.1016/S0022-5223(98)70417-9
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Bicarbonates.
Reoperative coronary artery bypass grafting presents unique challenges for myocardial preservation.
The purpose of this study was to compare oxygenated blood cardioplegia with oxygenated crystalloid cardioplegia during reoperative coronary artery bypass grafting using transesophageal echocardiography to assess regional wall motion of the left ventricle before and after cardiopulmonary bypass.
Who Took Part
The age groups tagged for this paper are middle-aged adults, both men and women.
Sixty-one patients undergoing reoperative coronary artery bypass grafting were prospectively randomized to receive oxygenated blood cardioplegia or oxygenated crystalloid cardioplegia delivered with a combined antegrade-retrograde technique.
How the Study Was Run
The design is described as randomized.
The participants were allocated by chance, so the Bicarbonates group and the comparison group should start out alike.
Transgastric short axis views of the left ventricle were made with transesophageal echocardiography during the operation before cardiopulmonary bypass and immediately after cardiopulmonary bypass.
Regional wall motion was graded by a blinded observer, and before cardiopulmonary bypass scores were compared with after cardiopulmonary bypass scores.
What Was Measured
The subject headings attached to it are Bicarbonates, Calcium Chloride, Cardioplegic Solutions, Coronary Artery Bypass, Crystalloid Solutions, Echocardiography, Transesophageal and Heart Arrest, Induced.
What This Means in Plain Language
The paper is a randomized study of Bicarbonates.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 1998 (The Journal of thoracic and cardiovascular surgery), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.