Effects of H1 antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging

What Was Tested

This randomized controlled trial paper looks at Bradykinin.

Quantification of these responses and studies of the mediator mechanisms underlying them have been limited by the lack of appropriate techniques to investigate them.

Why It Was Studied

Histamine plays an important part in the cutaneous weal and flare response which underlies many allergic skin conditions.

To address this the researchers have used two relatively new techniques, scanning laser Doppler imaging (LDI) and dermal microdialysis to measure changes in skin blood flow and the release of histamine within the weal and flare, following intradermal injection of histamine or bradykinin.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Bradykinin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Bradykinin.

What Was Measured

To address this the researchers have used two relatively new techniques, scanning laser Doppler imaging (LDI) and dermal microdialysis to measure changes in skin blood flow and the release of histamine within the weal and flare, following intradermal injection of histamine or bradykinin.

These measurements have been made both in the absence and presence of the H1 receptor blockers cetirizine and loratadine.

PubMed files the paper under topics including Bradykinin, Cetirizine, Dermatitis, Allergic Contact, Histamine, Histamine H1 Antagonists, Histamine Release and Laser-Doppler Flowmetry.

What This Means in Plain Language

The paper is a randomized and double-blind study of Bradykinin.

The publication is from 1998 (The British journal of dermatology), a journal based in England.

More context: the Bradykinin compound page, all human trials.