Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: lack of impact of different modes of GH administration.

What Was Tested

The paper reports a study of Human Growth Hormone, published as a randomized controlled trial.

The regulation of leptin production in humans is poorly understood but appears to depend on total body fat, changes in energy intake and insulin levels.

Since growth hormone (GH) is an important regulator of both lipid metabolism and insulin secretion and action, the researchers tested whether GH status directly or indirectly regulates leptin secretion.

Who Took Part

By PubMed's age tags, the people studied were children, teenagers and adults, both men and women.

Circadian serum leptin concentrations were measured in GH-deficient patients in two different protocols involving different modes of acute and prolonged GH exposure.

How the Study Was Run

The design is described as randomized.

Because people in this Human Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

The regulation of leptin production in humans is poorly understood but appears to depend on total body fat, changes in energy intake and insulin levels.

Since growth hormone (GH) is an important regulator of both lipid metabolism and insulin secretion and action, the researchers tested whether GH status directly or indirectly regulates leptin secretion.

PubMed files the paper under topics including Circadian Rhythm, Human Growth Hormone, Leptin, Obesity and Proteins.

What This Means in Plain Language

The paper is a randomized study of Human Growth Hormone.

The publication is from 1998 (European journal of endocrinology), a journal based in England.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.