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Fluoride salts are no better at preventing new vertebral fractures than calcium-vitamin D in postmenopausal osteoporosis: the FAVOStudy.
Plain-language guide to PMID 9692071 (1998): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 354 women.
Key Facts
- PMID
- 9692071
- Journal
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Meunier PJ et al. (12 authors)
- DOI
- 10.1007/s001980050041
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The researchers conducted a 2-year multicenter, prospective, randomized, double-masked clinical trial in 354 osteoporotic women with vertebral fractures (mean age 65.7 years).
A 1-year open follow-up on Ca-D was obtained in 124 patients.
Who Took Part
The abstract describes 354 women taking part.
The age groups tagged for this paper are middle-aged adults and older adults, women only.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and multicenter study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.
What Was Measured
The subject headings attached to it are Bone Density, Calcium, Ergocalciferols, Fluorides, Fractures, Spontaneous, Osteoporosis, Postmenopausal and Phosphates.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 354 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 1998 (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.