5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone.

What Was Tested

The paper reports a study of Growth Hormone and Hydrocortisone, published as a randomized controlled trial.

The researchers report the effects of acute administration of hydrocortisone in normal volunteers on a neuroendocrine model of 5-HT1A receptor function.

Who Took Part

PubMed indexes the participants as teenagers and adults, men only.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Growth Hormone, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Growth Hormone could be set against what happens without it.

Each person switched between Growth Hormone and the comparison at some point, usually with a gap in between.

What Was Measured

Topics PubMed links to this paper include Affect, Analysis of Variance, Growth Hormone, Hydrocortisone, Prolactin, Receptors, Serotonin and Receptors, Serotonin, 5-HT1.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Growth Hormone and Hydrocortisone.

The publication is from 1998 (Psychopharmacology), a journal based in Germany.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.