Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man

What Was Tested

This randomized controlled trial paper looks at Endothelin-1 in the context of low blood pressure and orthostatic hypotension.

The researchers investigated the involvement of endothelin-1 in the blood pressure response to the oxygen carrier diaspirin cross-linked hemoglobin (DCLHb) in stroke patients.

Who Took Part

The study group was 72 patients.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The patients were allocated by chance, so the Endothelin-1 group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with Endothelin-1 could be set against what happens without it.

Blood pressure and heart rate were measured every 15 min and plasma concentrations of endothelin-1, catecholamines, renin, vasopressin and atrial natriuretic peptide were measured before and 24 and 66 h after the start of the infusions.

What Was Measured

PubMed files the paper under topics including Acute Disease, Aspirin, Blood Pressure, Blood Substitutes, Brain Ischemia, Endothelin-1 and Hemoglobins.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Endothelin-1 in 72 patients in people with low blood pressure and orthostatic hypotension.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (Journal of hypertension), a journal based in Netherlands.

More context: the Endothelin-1 compound page, Low blood pressure and orthostatic hypotension research.