Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study

What Was Tested

The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.

Who Took Part

According to the abstract, 12 patients were involved.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.

The methods mention a period of 14 days.

What Was Measured

The subject headings attached to it are Action Potentials, Amyotrophic Lateral Sclerosis, Muscle, Skeletal and Vitamin B 12.

What This Means in Plain Language

The paper is a randomized and double-blind study of Cyanocobalamin (Vitamin B12) in 12 patients over 14 days.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1998 (Muscle & nerve), a journal based in United States.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.