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A controlled trial of desmopressin and behavioral therapy for nocturnal enuresis
Plain-language guide to PMID 9854601 (1998): double-blind randomized controlled trial study of Vasopressin and Desmopressin in 226 children.
Key Facts
- PMID
- 9854601
- Journal
- Medicine
- Year
- 1998
- Study type
- Randomized Controlled Trial
- Authors
- Kahan E et al. (4 authors)
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vasopressin and Desmopressin.
The combination of desmopressin (DDAVP) and behavioral therapy for treatment of nocturnal enuresis was compared with use of each of these modes alone.
The researchers randomly assigned 226 enuretic children being treated in primary care clinics of a major medical center in the largest health maintenance organization in Israel into 3 groups: Group A) DDAVP plus behavioral therapy (double-blind); Group B) behavioral therapy plus placebo (double-blind); and Group C) DDAVP alone (open group).
Who Took Part
The study group was 226 children.
The age groups tagged for this paper are children and teenagers, both men and women.
All patients were followed for 2 months after completion of treatment.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.
Blinding on both sides kept the children and researchers unaware of who received Vasopressin.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
The methods mention a period of 2 months.
What Was Measured
The researchers randomly assigned 226 enuretic children being treated in primary care clinics of a major medical center in the largest health maintenance organization in Israel into 3 groups: Group A) DDAVP plus behavioral therapy (double-blind); Group B) behavioral therapy plus placebo (double-blind); and Group C) DDAVP alone (open group).
PubMed files the paper under topics including Behavior Therapy, Combined Modality Therapy, Deamino Arginine Vasopressin, Enuresis, Recurrence and Renal Agents.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 226 children over 2 months.
The publication is from 1998 (Medicine), a journal based in United States.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.