Intermittent antegrade hyperkalaemic warm blood cardioplegia supplemented with magnesium prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The influence of the addition of magnesium on myocardial protection with intermittent antegrade warm blood hyperkalaemic cardioplegia in patients undergoing coronary artery surgery was investigated and compared with intermittent antegrade warm blood hyperkalaemic cardioplegia only.

Who Took Part

The age groups tagged for this paper are middle-aged adults, both men and women.

Twenty-three patients undergoing primary elective coronary revascularization were randomized to one of two different techniques of myocardial protection.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the first group, myocardial protection was induced using intermittent antegrade warm blood hyperkalaemic cardioplegia.

In the second group, the same technique was used except that magnesium was added to the cardioplegia.

Intracellular substrates (ATP, lactate and amino acids) were measured in left ventricular biopsies collected 5 min after institution of cardiopulmonary bypass, after 30 min of ischaemic arrest and 20 min after reperfusion.

What Was Measured

The subject headings attached to it are Adenosine Triphosphate, Amino Acids, Biopsy, Blood, Calcium Channel Blockers, Cardioplegic Solutions and Coronary Artery Bypass.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1998 (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.