Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis. Pelvic Pain Study Group

What Was Tested

The paper reports a study of Leuprolide in the context of chronic pain: fibromyalgia & crps and endometriosis, published as a randomized controlled trial.

Who Took Part

PubMed indexes the participants as teenagers, adults and middle-aged adults, women only.

Women 18-45 years of age with moderate to severe pelvic pain of at least 6 months' duration underwent extensive, noninvasive diagnostic testing and laboratory evaluation, including pelvic ultrasound, complete blood count, determination of erythrocyte sedimentation rate, and endocervical cultures.

The accuracy of the clinical diagnosis of endometriosis was evaluated by posttreatment laparoscopy.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Leuprolide.

The comparison arm used a placebo, so changes seen with Leuprolide could be set against what happens without it.

What Was Measured

Topics PubMed links to this paper include Algorithms, Chronic Disease, Endometriosis, Laparoscopy, Leuprolide and Pelvic Pain.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Leuprolide in people with chronic pain: fibromyalgia & crps.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1999 (Obstetrics and gynecology), a journal based in United States.

More context: the Leuprolide compound page, Chronic pain: fibromyalgia & CRPS research, Endometriosis research.