What is C-Peptide?
The 31-amino-acid fragment cut from proinsulin when insulin is made; it has been given as an investigational treatment in a few trials.
C-Peptide in the library · · Human Trials · What are peptides?
11 registered trials · 3 indexed papers · 716 human / 20 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
The 31-amino-acid fragment cut from proinsulin when insulin is made; it has been given as an investigational treatment in a few trials.
Type: Peptide.
Definition (National Library of Medicine)
“The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar insulin and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.”
- MeSH: C-Peptide
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when C-Peptide is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (11)
Peer-reviewed studies (3)
| Paper | Authors | Journal | Year | Type |
|---|---|---|---|---|
| Orforglipron, an oral non-peptide glucagon-like peptide-1 receptor agonist, improves markers of β-cell function and insulin sensitivity in type 2 diabetes | Rosenstock J et al. | Diabetes, obesity & metabolism | 2025 | Randomized Controlled Trial |
| Predictors of HbA1c reduction and hypoglycemia in type 2 diabetes mellitus individuals switching from premixed to basal insulin: an exploratory analysis of optimization study | Yang W et al. | Current medical research and opinion | 2022 | Clinical Trial, Phase IV |
| C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy | Ekberg K et al. | Diabetes care | 2007 | Randomized Controlled Trial |
More cited research
- Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement (2025, human observational)
- A new C-Peptide correction model used to assess bioavailability of regular human insulin (None, human trial (non-randomized))
- Blood glucose and serum C-peptide after a single chlorpropamide dose (None, human trial (non-randomized))
- Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation (2021, animal)
- Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice (2018, animal)
- In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis (2010, animal)
- Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes (2009, animal)
Conditions researched
- Heart repair: after heart attack, heart failure & enlarged heart
- Insulin resistance, prediabetes & type 2 diabetes
- Neuropathy and CRPS
Related compounds
- ACTH (Corticotropin)
- Exenatide
- Insulin Aspart
- Insulin Glargine
- Insulin Lispro
- Liraglutide
- Lixisenatide
- Octreotide
- Somatostatin
- Amylin (Islet Amyloid Polypeptide)
FAQ
What is C-Peptide?
The 31-amino-acid fragment cut from proinsulin when insulin is made; it has been given as an investigational treatment in a few trials.
How many registered human trials study C-Peptide?
The PeptideWhiz trial index lists 11 registered trials for C-Peptide, the most recent from 2025.
How much published research exists on C-Peptide?
The PeptideWhiz paper index links 3 PubMed papers to C-Peptide; by study type, 716 human and 20 animal studies.
Which conditions is C-Peptide researched for?
Heart repair: after heart attack, heart failure & enlarged heart, Insulin resistance, prediabetes & type 2 diabetes, Neuropathy and CRPS.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).