What is Lixisenatide?

A 44-amino-acid once-daily GLP-1 receptor agonist based on exendin-4; sold as Adlyxin/Lyxumia and in Soliqua with insulin glargine.

Lixisenatide in the library · Metabolic & Weight Peptides · Human Trials · What are peptides?

66 registered trials · 111 indexed papers · 186 human / 6 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 44-amino-acid once-daily GLP-1 receptor agonist based on exendin-4; sold as Adlyxin/Lyxumia and in Soliqua with insulin glargine.

Type: GLP-1 receptor agonist peptide.

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Lixisenatide is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (66)

TrialPhaseStatusYearEnrolled
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 DiabetesPhase 4not yet recruiting2026324
A Study to Investigate Safety and Efficacy of iGlarLixi in Adult Patients With Type 2 Diabetes MellitusPhase 4completed2025105
Efficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral AgentsPhase 4recruiting20251316
Evaluation of the Efficacy and Safety of GLP-1 Receptor Agonist Therapy In Steroid-Induced DiabetesPhase 4enrolling by invitation2025100
iGlarLixi CGM Study in Chinese T2D Individuals After OADsPhase 4recruiting2024678
The Effect of Lixisenatide on the Effect of Pituitary HormonesPhase 4unknown202310
iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)Phase 3completed2022582
Effect of Soliqua 100/33 on Time in Range From Continuous Glucose Monitoring in Insulin-naive Patients With Very Uncontrolled Type 2 Diabetes MellitusPhase 4completed2022124
Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Studyactive not recruiting2021781430
Evaluation of Insulin Glargine/Lixisenatide Fixed Ratio Combination in Patients With Type 2 Diabetes Insufficiently Controlled With Oral Antidiabetic Drug(s)Phase 3completed2019878
Comparison of the Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Ratio Combination to Insulin Glargine in Patients With Type 2 Diabetes Insufficiently Controlled on Basal InsulinPhase 3completed2019426
Study Comparing the Efficacy and Safety of Insulin Glargine (Basal Insulin)/Lixisenatide (GLP-1 Receptor Agonist) Combination (Soliqua™) in Patients With Type 2 Diabetes Mellitus (T2DM)Phase 3completed2019265
Study to Evaluate the Effect of Lixisenatide in Patient With Parkinson's DiseasePhase 2completed2018156
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-India)Phase 3completed2018247
Efficacy and Safety of Soliqua Versus Lantus in Ethnically/Racially Diverse Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Antidiabetic AgentsPhase 3terminated2018241
The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South AsiansPhase 4completed2018119
A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM)Phase 1completed201723
Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mellitus Who Elect to Fast During RamadanPhase 4completed2017184
Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IGlarLixiPhase 3completed2017161
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension PeriodPhase 3completed2016514
Postprandial Glucodynamic Response to Insulin Glargine/Lixisenatide Fixed Ratio Combination in Japanese Patients With Type 2 Diabetes MellitusPhase 1completed201620
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Lixisenatide on Top of Oral Anti-diabetic Drugs (OADs) With Type 2 Diabetes in JapanPhase 3completed2016321
Efficacy and Safety of LixiLan Versus Insulin Glargine Alone Both With Metformin in Japanese With Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Antidiabetic DrugsPhase 3completed2016513
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Insulin Glargine Alone on Top of Oral Anti-diabetic Drugs (OADs) With Type 2 Diabetes in JapanPhase 3completed2016521
Effects of a GLP-1 Receptor Agonist on Functional Activation and Connectivity of the Braincompleted201630
Evaluation of Lixisenatide Efficacy in Diabetes Mellitus Type 2 With Failure of Other GLP-1 AnalogPhase 4terminated20162
The Impact of Lixisenatide on Postprandial Glucose Tolerance in Pancreatectomised Subjectscompleted201524
Effects of Victoza® Versus Lyxumia® on Gastroesophageal Reflux, Gastric Emptying and Gastric Acid SecretionPhase 1terminated2015109
Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic PatientsPhase 2terminated20152
Lixisenatide-The Effects on Glucose and Lipid Metabolism in Type 2 DiabetesPhase 4completed20148
Pathophysiological Study of the Increase in Pancreatic Volume in Type 2 Diabetes Treatments.terminated20145
Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DMPhase 3completed20141170
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 DiabetesPhase 3completed2014736
Feasibility of Once/Daily Administered GLP/1 Receptoragonist (Lixisenatide) in Combination With Basal InsulinPhase 3completed201410
Effect of Lixisenatide on Postprandial Plasma Glucose Compared to Sitagliptin in Combination With Insulin GlarginePhase 4completed2014136
Effect of LIXIsenatide on the Renal SystemPhase 4completed201440
The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a)Phase 4unknown201440
Efficacy and Safety of Lixisenatide Versus Placebo on Top of Basal Insulin and/or Oral Antidiabetic Treatment in Older Type 2 Diabetic PatientsPhase 3completed2013350
Efficacy and Safety of Liraglutide Versus Lixisenatide as add-on to Metformin in Subjects With Type 2 DiabetesPhase 4completed2013404
Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic PatientsPhase 3completed2013894

Peer-reviewed studies (111)

PaperAuthorsJournalYearType
iGlarlixi for the simplification of more complex insulin regimens in type 2 diabetes patients with good glycaemic controlTaybani ZJ et al.Frontiers in endocrinology2026Observational Study
Efficacy and Safety of iGlarLixi Versus IDegAsp by Baseline Age, Disease Duration and HbA1c in Chinese People With Type 2 Diabetes: Post Hoc Analyses of the Soli-D StudyZhang S et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Impact of iGlarLixi on Glycaemic Control Depth and Variability in Asian Pacific People With Type 2 Diabetes: A Post Hoc Analysis of LixiLan-O-AP and LixiLan-L-CNNi J et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Impact of Time of Injection on the Efficacy and Safety of iGlarLixi Versus IDegAsp in Chinese People With Type 2 Diabetes: Exploratory Analysis of the Soli-D StudyLi X et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trialFountoulakis N et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Insulin therapy DE-intensificAtion with iGlarLixi: A phase 4, open-label, parallel-group randomised controlled trialNovodvorský P et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Efficacy and safety of iGlarLixi versus IDegAsp by baseline β-cell function in Chinese people with type 2 diabetes: Exploratory analyses of the Soli-D studyGu W et al.Diabetes, obesity & metabolism2026Randomized Controlled Trial
Long-term effectiveness of iGlarLixi treatment in people with type 2 diabetes in the United States: The soli-durability 24-month observational studyMalik RA et al.Diabetes, obesity & metabolism2025Observational Study
Efficacy and safety of switching to iGlarLixi from premixed insulins in people with type 2 diabetes: The Soli-SWITCH studyHaluzík M et al.Diabetes, obesity & metabolism2025Clinical Trial, Phase IV
Safety of iGlarLixi in Japanese People with Type 2 Diabetes: A Post-marketing Database StudyKaneto H et al.Advances in therapy2025Observational Study
Treatment satisfaction and time in range after 16 weeks of treatment with iGlarLixi in insulin-naive adults with suboptimally controlled type 2 diabetesShah VN et al.Diabetes, obesity & metabolism2025Clinical Trial, Phase IV
Effect of iGlarLixi on continuous glucose monitoring-measured time in range in insulin-naive adults with suboptimally controlled type 2 diabetesFrías JP et al.Diabetes, obesity & metabolism2025Clinical Trial, Phase IV
Effectiveness and safety of iGlarLixi in people with type 2 diabetes not at target on basal insulin and oral antidiabetic therapy in a prospective observational trialSeufert J et al.Diabetes, obesity & metabolism2025Observational Study
The efficacy and safety of iGlarLixi versus IDegAsp in Chinese people with type 2 diabetes suboptimally controlled with oral antidiabetic drugs: The Soli-D randomized controlled trialLiu M et al.Diabetes, obesity & metabolism2024Randomized Controlled Trial
Effect of lixisenatide on liquid gastric emptying in type 2 diabetes - Implications for the use of GLP-1 receptor agonists before proceduresKovoor JG et al.Journal of diabetes and its complications2024Randomized Controlled Trial
Real-world effectiveness and safety of insulin glargine 100 U/mL plus lixisenatide in adults with type 2 diabetes: An international, multicentre, 12-month, prospective observational studyMalik RA et al.Diabetes, obesity & metabolism2024Observational Study
Trial of Lixisenatide in Early Parkinson's DiseaseMeissner WG et al.The New England journal of medicine2024Randomized Controlled Trial
Comparison of efficacy and safety of insulin degludec/liraglutide and insulin glargine U-100/lixisenatide in individuals with type 2 diabetes mellitus using professional continuous glucose monitoringKawaguchi Y et al.Journal of diabetes investigation2024Randomized Controlled Trial
Diabetes remission and relapse following an intensive metabolic intervention combining insulin glargine/lixisenatide, metformin and lifestyle approaches: Results of a randomised controlled trialMcInnes N et al.Diabetes, obesity & metabolism2023Randomized Controlled Trial
iGlarLixi provides a higher derived time-in-range versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with type 2 diabetes: A post hoc analysisGuo X et al.Diabetes, obesity & metabolism2023Randomized Controlled Trial
The Durable Safety and Effectiveness of Lixisenatide in Japanese People with Type 2 Diabetes: The Post-Marketing Surveillance PRANDIAL StudyTerauchi Y et al.Advances in therapy2022Observational Study
Efficacy and safety benefits of iGlarLixi versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with suboptimally controlled type 2 diabetes on oral agents: The LixiLan-O-AP randomized controlled trialYang W et al.Diabetes, obesity & metabolism2022Randomized Controlled Trial
A study on pharmacokinetics, pharmacodynamics and safety of lixisenatide in children and adolescents with type 2 diabetesBarrientos-Pérez M et al.Pediatric diabetes2022Randomized Controlled Trial
Fixed-ratio combination of insulin glargine plus lixisenatide (iGlarLixi) improves ß-cell function in people with type 2 diabetesFerrannini E et al.Diabetes, obesity & metabolism2022Randomized Controlled Trial
Comparisons of efficacy and safety in insulin glargine and lixisenatide plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type 2 diabetesKawaguchi Y et al.Journal of diabetes investigation2022Randomized Controlled Trial
Benefit of insulin glargine/lixisenatide for reducing residual hyperglycaemia in Japan: Post hoc analysis of the LixiLan JP-O2 trialIizuka K et al.Diabetes, obesity & metabolism2021Clinical Trial
Effects of glucagon-like peptide-1 receptor agonists on secretions of insulin and glucagon and gastric emptying in Japanese individuals with type 2 diabetes: A prospective, observational studyKuwata H et al.Journal of diabetes investigation2021Observational Study
iGlarLixi reduces residual hyperglycemia in Japanese patients with type 2 diabetes uncontrolled on basal insulin: A post-hoc analysis of the LixiLan JP-L trialYabe D et al.Journal of diabetes investigation2021Clinical Trial
Efficacy of once-daily glucagon-like peptide-1 receptor agonist lixisenatide as an add-on treatment to basal insulin in Asian and white adults with type 2 diabetes mellitus: An individual-level pooled analysis of phase III studiesLiu F et al.Journal of diabetes investigation2021Randomized Controlled Trial
The Differential and Combined Action of Insulin Glargine and Lixisenatide on the Fasting and Postprandial Components of Glucose ControlGautier T et al.Journal of diabetes science and technology2021Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Lixisenatide?

A 44-amino-acid once-daily GLP-1 receptor agonist based on exendin-4; sold as Adlyxin/Lyxumia and in Soliqua with insulin glargine.

How many registered human trials study Lixisenatide?

The PeptideWhiz trial index lists 66 registered trials for Lixisenatide, the most recent from 2026.

How much published research exists on Lixisenatide?

The PeptideWhiz paper index links 111 PubMed papers to Lixisenatide; by study type, 186 human and 6 animal studies.

Which conditions is Lixisenatide researched for?

Delayed gastric emptying on GLP-1 medicines, Fat loss, obesity & body recomposition, Heart repair: after heart attack, heart failure & enlarged heart, Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Neuropathy and CRPS, Parkinson's disease.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research