Home › Peptides A to Z › CRH (Corticotropin-Releasing Hormone)What is CRH (Corticotropin-Releasing Hormone)? The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
CRH (Corticotropin-Releasing Hormone) in the library · · Human Trials · What are peptides?
18 registered trials · 384 indexed papers · 524 human / 480 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Type: Peptide hormone.
Definition (National Library of Medicine) “A peptide of about 41 amino acids that stimulates the release of adrenocorticotropic hormone. crh is synthesized by neurons in the paraventricular nucleus of the hypothalamus. After being released into the pituitary portal circulation, crh stimulates the release of ACTH from the pituitary gland. crh can also be synthesized in other tissues, such as placenta; adrenal medulla; and testis.”
MeSH: Corticotropin-Releasing Hormone Human research The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when CRH (Corticotropin-Releasing Hormone) is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (18) Peer-reviewed studies (384) Paper Authors Journal Year Type Blunted arginine vasopressin secretion in individuals experiencing a major depressive episode with comorbid post-traumatic stress disorder: Results from an exploratory study using copeptin as a surrogate marker Hu H et al. Journal of neuroendocrinology 2026 Clinical Trial, Phase II A positive corticotropin-releasing hormone test may obviate the need for petrosal sinus sampling in patients with cushing's disease Losa M et al. Journal of endocrinological investigation 2026 Observational Study The effect of corticotropin-release hormone on duodenal permeability and immune activation in healthy volunteers in a double-blind placebo-controlled study Schol J et al. American journal of physiology. Gastrointestinal and liver physiology 2025 Randomized Controlled Trial Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial Asla Q et al. Scientific reports 2025 Randomized Controlled Trial Associations between hypothalamic-pituitary-adrenal (HPA) axis hormone levels, major depression features and antidepressant effects of ketamine Georgiou P et al. Journal of affective disorders 2025 Randomized Controlled Trial Characterisation of biomarkers of intestinal barrier function in response to a high fat/high carbohydrate meal and corticotropin releasing hormone Mogilevski T et al. PloS one 2024 Randomized Controlled Trial Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study Huang IH et al. American journal of physiology. Gastrointestinal and liver physiology 2024 Randomized Controlled Trial Corticotropin-Releasing Factor receptor 1 (CRF1) antagonism in patients with alcohol use disorder and high anxiety levels: effect on neural response during Trier Social Stress Test video feedback Lee MR et al. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2023 Randomized Controlled Trial Serum oxytocin and corticotropin-releasing hormone levels in the third trimester of pregnancy for predicting postpartum depression in Thai women Oon-Arom A et al. Asian journal of psychiatry 2023 Observational Study Transcutaneous vagal nerve stimulation protects against stress-induced intestinal barrier dysfunction in healthy adults Mogilevski T et al. Neurogastroenterology and motility 2022 Randomized Controlled Trial Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia Auchus RJ et al. The Journal of clinical endocrinology and metabolism 2022 Clinical Trial, Phase II Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial Mei J et al. Medicine 2021 Clinical Study Efficacy and safety of Buzhong Yiqi Decoction in improving cancer-related fatigue and immunity of cervical carcinoma patients: A protocol of randomized controlled trial Hu J et al. Medicine 2021 Clinical Study Inferior petrosal sinus sampling and stimulation with CRH: 15 years of experience in a tertiary hospital González Fernández L et al. Endocrinologia, diabetes y nutricion 2021 Observational Study Tildacerfont in Adults With Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies Sarafoglou K et al. The Journal of clinical endocrinology and metabolism 2021 Clinical Trial, Phase II Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain-intestine interaction in the treatment of insomnia Zhang Y et al. Medicine 2021 Clinical Study Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study Quero CD et al. Nutrients 2021 Randomized Controlled Trial Molecular Imaging Targeting Corticotropin-releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm Walia R et al. The Journal of clinical endocrinology and metabolism 2021 Clinical Trial Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial Khalighi Sikaroudi M et al. Complementary medicine research 2020 Randomized Controlled Trial Effects of acupuncture on the hypothalamus-pituitary-adrenal axis in chronic insomnia patients: a study protocol for a randomized controlled trial Liu C et al. Trials 2019 Clinical Study CRH stimulation improves (18)F-FDG-PET detection of pituitary adenomas in Cushing's disease Boyle J et al. Endocrine 2019 Clinical Trial Can Placental Corticotropin-Releasing Hormone Inform Timing of Antenatal Corticosteroid Administration? Swales DA et al. The Journal of clinical endocrinology and metabolism 2019 Clinical Trial ACTH and cortisol responses to CRH in acute, subacute, and prolonged critical illness: a randomized, double-blind, placebo-controlled, crossover cohort study Peeters B et al. Intensive care medicine 2018 Randomized Controlled Trial Sex differences in the ACTH and cortisol response to pharmacological probes are stressor-specific and occur regardless of alcohol dependence history Anthenelli RM et al. Psychoneuroendocrinology 2018 Randomized Controlled Trial Gonadotropin-releasing hormone agonist in premenopausal women does not alter hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone Gavin KM et al. American journal of physiology. Endocrinology and metabolism 2018 Randomized Controlled Trial Kisspeptin Is a Novel Regulator of Human Fetal Adrenocortical Development and Function: A Finding With Important Implications for the Human Fetoplacental Unit Katugampola H et al. The Journal of clinical endocrinology and metabolism 2017 Observational Study Plasma cortisol response cannot be classically conditioned in a taste-endocrine paradigm in humans Petrakova L et al. Psychopharmacology 2017 Randomized Controlled Trial Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans Petrakova L et al. Biological psychology 2017 Randomized Controlled Trial Effects of Insufficient Sleep on Pituitary-Adrenocortical Response to CRH Stimulation in Healthy Men Guyon A et al. Sleep 2017 Clinical Trial Regulation of Pulsatile and Entropic ACTH Secretion Under Fixed Exogenous Secretagogue Clamps Roelfsema F et al. The Journal of clinical endocrinology and metabolism 2017 Randomized Controlled Trial
More cited research Differentiating hypothalamic from pituitary adrenal insufficiency: underlying causes and diagnostic utility of the corticotropin-releasing hormone and growth ho (2026, human observational)Gene × Environment interaction and resilience: effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes (2012, human observational)Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and (2010, human case report)The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled recep (2006, human observational)Synergistic regulation of itch behaviors by corticotropin-releasing hormone neurons in the medial prefrontal cortex (2026, animal)A CRH Receptor Type 1 Agonist Increases GABA Transmission to GnRH Neurons in a Circulating-Estradiol-Dependent Manner (2020, animal)Characterization and gonadal hormone regulation of a sexually dimorphic corticotropin-releasing factor receptor 1 cell group (2019, animal)Effect of corticotropin releasing hormone and corticotropin releasing hormone antagonist on biosynthesis of gonadotropin relasing hormone and gonadotropin relas (2018, animal)Conditions researched Anxiety and panic Anemia Atherosclerosis, cardiovascular disease & high blood pressure Chronic fatigue syndrome and ME Chronic pain: fibromyalgia & CRPS Delayed gastric emptying on GLP-1 medicines Dementia, Alzheimer's & cognitive decline Eczema Fat loss, obesity & body recomposition Fatigue & low energy (incl. midlife) Fight-or-flight and nervous system overdrive Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers Heart repair: after heart attack, heart failure & enlarged heart High-demand jobs: military, fire, police, EMT (and combat-sport athletes) Immune system (general) Insulin resistance, prediabetes & type 2 diabetes Low testosterone (without or alongside TRT) Lung health, asthma & COPD Lupus (SLE) Lymphedema and swelling Male fertility and sperm Migraine Multiple sclerosis Muscle disease (myopathy) Osteoarthritis, cartilage loss & avoiding joint replacement Parkinson's disease PCOS Post-surgical inflammation and surgery recovery Pregnancy and breastfeeding: safety notes Raynaud's Rheumatoid arthritis Sleep problems (incl. insomnia on peptides) Thyroid problems Related compounds FAQ What is CRH (Corticotropin-Releasing Hormone)? The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
How many registered human trials study CRH (Corticotropin-Releasing Hormone)? The PeptideWhiz trial index lists 18 registered trials for CRH (Corticotropin-Releasing Hormone), the most recent from 2021.
How much published research exists on CRH (Corticotropin-Releasing Hormone)? The PeptideWhiz paper index links 384 PubMed papers to CRH (Corticotropin-Releasing Hormone); by study type, 524 human and 480 animal studies.
Which conditions is CRH (Corticotropin-Releasing Hormone) researched for? Anxiety and panic, Anemia, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic fatigue syndrome and ME, Chronic pain: fibromyalgia & CRPS, Delayed gastric emptying on GLP-1 medicines, Dementia, Alzheimer's & cognitive decline, Eczema, Fat loss, obesity & body recomposition, Fatigue & low energy (incl. midlife), Fight-or-flight and nervous system overdrive, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Low testosterone (without or alongside TRT), Lung health, asthma & COPD, Lupus (SLE), Lymphedema and swelling, Male fertility and sperm, Migraine, Multiple sclerosis, Muscle disease (myopathy), Osteoarthritis, cartilage loss & avoiding joint replacement, Parkinson's disease, PCOS, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Raynaud's, Rheumatoid arthritis, Sleep problems (incl. insomnia on peptides), Thyroid problems.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).
Reported dosing ranges from research