What is Glutathione?

The body's main antioxidant.

Glutathione in the library · · Human Trials · What are peptides?

73 registered trials · 1193 indexed papers · 1330 human / 614 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

The body's main antioxidant. Discussed as a supporting compound, not a signaling peptide.

Registered human trials (73)

TrialPhaseStatusYearEnrolled
Adia Med of Winter Park LLC Autism Spectrum Disorder Research StudyPhase 1recruiting2026100
S-Acetyl Glutathione and Performance Recovery in Soccernot yet recruiting202620
Adia Med of Winter Park LLC Chronic Kidney Disease Research StudyPhase 1recruiting2026100
GAIP ASD Research StudyPhase 1recruiting2026100
Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of MelasmaPhase 2/Phase 3not yet recruiting202642
Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachetrecruiting202630
The Impact of Qualia Gluthathione+ on Blood Glutathione Levelscompleted202556
Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent Tablets on Subjects With Facial Dark Spots Such as Pimple Marks, Sunspots, Age Spots and Uneven Skin Tonecompleted202562
Comparison of Gingival Depigmentation Using Microneedling and Microneedling With Glutathione Gel - A Split Mouth Clinical Trialcompleted202515
Gingival Hyperpigmentation TreatmentPhase 2recruiting202530
Combination Gerotherapeutic Interventions for Healthspan ImprovementPhase 3active not recruiting202530
Effect of Double Nutri® Liposomal Encapsulation Technology on Human Absorption of Vitamin C and Glutathione Liquid Sachetcompleted202520
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemiarecruiting2025232
Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial HyperpigmentationPhase 2active not recruiting202560
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLCPhase 1recruiting202580
The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19EARLY_Phase 1withdrawn2025
Prevent Cardiac Surgery Associated AKI TrialPhase 2recruiting2024242
Ultrasound-Enhanced Delivery of Compound TXA Solution in Melasmarecruiting202435
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis RatsPhase 4completed202424
The Impact of Oral Glutathione on Oxidative Damage and Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Patientscompleted2023217
Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's DiseasePhase 2recruiting202256
Pharmacokinetics and Safety of a New Micellar Glutathione Formulationcompleted202216
Glutathione (GSH) Supplementation After Hospitalizationwithdrawn2022
Evaluation of the Relationship Between Oxidative Stress and Human Reproductionunknown202180
Avatrombopag in Patients With End-stage Liver Disease and ThrombocytopeniaPhase 4unknown2021150
Effect of Glutathione vs KI in Reducing SDF Staining When Used in Treatment of Primary Carious Teethunknown202160
Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Functioncompleted202039
Glutathione-rich Foods for Type 2 Diabetescompleted202012
SH-SS and GSH-GSSG Homeostasis in Post-stroke Patientscompleted202077
Treatment of Patients With Periorbital Hyperpigmentationcompleted202031
A Study of Glutathione in Children With Autism Spectrum DisorderPhase 4terminated20196
Setria Performance Blend Supplementationcompleted201925
Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge InfectionPhase 2completed201839
Effects of Glutathione on Immunity in Individuals Training for a Marathoncompleted201884
Oral Glutathione As A Skin Whitening AgentPhase 1completed201890
The Role of Oral Glutathione on Growth Parameters in Children With Cystic FibrosisPhase 2completed201760
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After TransplantationPhase 3completed2016157
Glutathione vs. Curcumin Clinical TrialPhase 1/Phase 2unknown201675
The Production of Reactive Oxygen Species in Response to Glutathione Supplementation and Acute Exercisecompleted201620
Oral Glutathione Supplementation in Older Healthy Adults and Its Effect on the Number of Healthy Days Experienced During Four Months of Supplementation Compared to Placebocompleted2015124

Peer-reviewed studies (1193)

PaperAuthorsJournalYearType
Association of Vitamin D Status with Neurobiological Biomarkers in Healthy Elderly PopulationSanoop E et al.La Clinica terapeutica2026Observational Study
Exploration of Safety, Pharmacokinetics and Selected Pharmacodynamic Mechanisms of High-Dose Se-Methylselenocysteine, L-Selenomethionine and Selenite in a Phase Ib Trial in Cancer PatientsTurnbull CM et al.International journal of molecular sciences2026Randomized Controlled Trial
Ferroptosis and sepsis-induced myocardial injury: a prospective clinical studyChen D et al.BMC infectious diseases2026Observational Study
Formulation-dependent differences in systemic glutathione availability: Comparative pharmacokinetics of orally dissolving film and tablet formulations in healthy adultsJung ES et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2026Randomized Controlled Trial
Cognitive and Memory Decline in Thyroid Disorders: A Biomarker Based Cross Sectional Study in Aging AdultsMadhurya M et al.La Clinica terapeutica2026Observational Study
Phase 1 dose-escalation trial combining sulfasalazine and stereotactic radiosurgery in patients with recurrent glioblastomaSkeie BS et al.Redox biology2026Clinical Trial, Phase I
Evaluation of oxidative stress in acute pancreatitisPădureanu V et al.Frontiers in immunology2026Observational Study
A randomized, double-blind, controlled, parallel group study with amustaline/glutathione pathogen reduced red blood cells in regions at potential risk for Zika virus transfusion-transmitted infections (RedeS Study)-protocol for a phase 3 clinical trialAyala EFC et al.Trials2026Clinical Study
Metabolic and Antioxidant Status, Telomere Lengths of Individuals With Prediabetes in Context of 3 Months of Insoluble Dietary Fibre Intake During the SARS-CoV2 PandemicKhalangot M et al.Endocrinology, diabetes & metabolism2026Randomized Controlled Trial
Clinical investigations and mechanistic insights into the antioxidant effects of drugs post-cataract surgeryTang GPakistan journal of pharmaceutical sciences2026Randomized Controlled Trial
Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox-function associations in older adults: a secondary analysis of a randomized crossover trialRamos-Hernández R et al.Biogerontology2026Randomized Controlled Trial
Weizmannia coagulans BC99 alleviates alcohol-induced oxidative stress and gut barrier dysfunction via modulation of butyrate metabolism: A randomized, double-blind, placebo-controlled trialWang Y et al.Free radical biology & medicine2026Randomized Controlled Trial
Changes in Glutathione Metabolites and Reactive Oxygen Species from Baseline to Post-Treatment in Breast Cancer Survivors with Psychoneurological Symptoms Receiving AcupunctureLi H et al.Integrative cancer therapies2026Clinical Trial, Phase II
Fructose-sweetened beverages induce diurnal redox dysregulation in pediatric MASLDHuneault HE et al.Redox biology2026Randomized Controlled Trial
Sodium benzoate treatment linked to increased glutathione levels and improved positive and negative symptoms, global function, and quality of life in patients with clozapine-resistant schizophrenia: secondary analysis of a randomized clinical trialLin CH et al.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2026Randomized Controlled Trial
Inflammatory and Immune Effects of Pollution: Comparison Between Patients With Asthma and Healthy IndividualsSoler-Segovia D et al.Journal of investigational allergology & clinical immunology2026Randomized Controlled Trial
Amustaline/glutathione pathogen-reduced red cell hemoglobin utilization in complex cardiac surgery: A post hoc analysis of the phase 3 ReCePI trialWelsby IJ et al.Transfusion2026Randomized Controlled Trial
Time-Dependent Changes in Salivary Antioxidants After 5-ALA Photodynamic Therapy vs. Clobetasol in Oral Lichen Planus: A Randomized Clinical TrialWiśniewski P et al.International journal of molecular sciences2025Randomized Controlled Trial
Redox Homeostasis and Antioxidant Response After Bariatric Surgery in Severe Obesity: Insights from a Controlled Clinical CohortIon RM et al.Medicina (Kaunas, Lithuania)2025Observational Study
The Effect of N-Acetylcysteine (NAC) on Neurometabolites and Cognitive Function in Adults With Alcohol Use Disorder: A Preliminary Randomized Controlled TrialDunbar KY et al.Neuropsychopharmacology reports2025Randomized Controlled Trial
Efficacy and safety of injectable sodium hyaluronate with vitamin C, tranexamic acid, and glutathione for pigmented dark circlesGuo F et al.The Journal of dermatological treatment2025Randomized Controlled Trial
Metabolic impact of dietary glycine supplementation in individuals with severe obesityTan HC et al.Scientific reports2025Clinical Trial
Transfusion of Amustaline/Glutathione Pathogen-reduced Red Blood Cells in Cardiac Surgery: A Randomized Phase 3 Clinical TrialSekela ME et al.Anesthesiology2025Clinical Trial, Phase III
A randomized, double-blind, placebo-controlled trial of N-acetylcysteine as an adjuvant treatment for alcohol use disorderSchuch JB et al.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025Randomized Controlled Trial
Effectiveness of oral glutathione in reducing nitric oxide and IL-1α concentrations for clinical improvement in mild to moderate acne vulgaris: a randomized controlled trialMawu FO et al.Acta dermatovenerologica Alpina, Pannonica, et Adriatica2025Randomized Controlled Trial
A Standardised Exercise Protocol to Induce Oxidative Stress in Humans: Validation with a Dietary Polyphenol InterventionKamati OV et al.Nutrients2025Randomized Controlled Trial
Effects of Acute and Repeated Ischemic Preconditioning on Recovery from Muscle Fatigue after High-Intensity Swim Training in Male Amateur SwimmersWu Y et al.Journal of sports science & medicine2025Randomized Controlled Trial
The serum levels and clinical significance of ferroptosis markers in patients with aneurysmal subarachnoid hemorrhage who underwent aneurysm clipping surgeryWu X et al.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2025Observational Study
Jaboticaba berry (Myrciaria jaboticaba) consumption improves plasma GSH levels and accelerates muscle recovery following exercise-induced muscle damage: a randomized, placebo-controlled trialJunior OJFR et al.European journal of nutrition2025Randomized Controlled Trial
The effect of cannabidiol on neurometabolite levels in alcohol use disorderHurzeler T et al.Alcohol and alcoholism (Oxford, Oxfordshire)2025Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Glutathione?

The body's main antioxidant.

How many registered human trials study Glutathione?

The PeptideWhiz trial index lists 73 registered trials for Glutathione, the most recent from 2026.

How much published research exists on Glutathione?

The PeptideWhiz paper index links 1193 PubMed papers to Glutathione; by study type, 1330 human and 614 animal studies.

Which conditions is Glutathione researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, High cholesterol and statins, High ferritin and iron overload, Acne, Anemia, Anti-aging & longevity, Anxiety and panic, Autism support, Chronic and systemic inflammation, Chronic fatigue syndrome and ME, Chronic pain: fibromyalgia & CRPS, Cognition, focus & brain performance, Concussion, traumatic brain injury & stroke recovery, Dementia, Alzheimer's & cognitive decline, Diabetic retinopathy and glaucoma, Endometriosis, Eyes: macular degeneration & retinal health, Fat loss, obesity & body recomposition, Fatigue & low energy (incl. midlife), Fatty liver & elevated liver enzymes, Female fertility, Gum disease (periodontal) & oral health, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Low blood pressure and orthostatic hypotension, Lung health, asthma & COPD, Lupus (SLE), Male fertility and sperm, Menopause & perimenopause, Multiple sclerosis, Muscle disease (myopathy), Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Pancreatitis (after the acute phase), Parkinson's disease, PCOS, PMDD (premenstrual dysphoric disorder), Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Psoriasis and psoriatic arthritis, Recurring UTIs, Rheumatoid arthritis, Seasonal allergies, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep problems (incl. insomnia on peptides), Tendon, ligament, muscle & joint injuries (incl. athletes), Thick blood and blood clots, Varicose veins.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research