What is Cyanocobalamin (Vitamin B12)?

A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.

Cyanocobalamin (Vitamin B12) in the library · · Human Trials · What are peptides?

201 registered trials · 292 indexed papers · 452 human / 27 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Cyanocobalamin is described as a synthetic form of vitamin B12, an essential nutrient required for DNA synthesis, red blood cell formation and neurological function. B12 deficiency is described as able to lead to anemia, neuropathy, cognitive impairment and fatigue.

It is described as a cobalt-containing, water-soluble micronutrient essential for cellular methylation reactions and mitochondrial metabolic function.

Research context (as described)

  • Laboratory and clinical research endpoints described include homocysteine modulation, methylmalonic acid levels, one-carbon metabolism biomarkers, mitochondrial respiration parameters and gene-expression responses tied to DNA synthesis and genomic stability.
  • The library mentions B12 as a lab marker and as part of an oral methylated B complex in the supporting-supplements page.

Registered human trials (201)

TrialPhaseStatusYearEnrolled
Vitamin B12 Absorption StudyPhase 4completed202612
Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patientscompleted202660
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integrationnot yet recruiting202642
Hand and Foot Bath for Taxane-Induced Peripheral NeurotoxicityPhase 4not yet recruiting202678
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-weekPhase 3not yet recruiting202623
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healingrecruiting2025100
A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by MouthPhase 4completed202546
Bioequivalence Study of WP205 in Healthy ParticipantsPhase 1completed202520
Combination Gerotherapeutic Interventions for Healthspan ImprovementPhase 3active not recruiting202530
Effectiveness of Vitamin b12 Versus Kenalog on Traumatic Ulcer Associated With Orthodontic Treatmentcompleted202582
Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performanceenrolling by invitation202520
Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patientscompleted202550
A Study to Evaluate the Effects and Safety of Hydroxocobalamin in Participants With Combined Methylmalonic Academia (cblC Type)Phase 3not yet recruiting202520
ICOPE INTENSE-K Pilot Studyrecruiting202540
Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocolnot yet recruiting2025207
Study on the Improvement of Microcirculation in Patients With Sepsis by Vitamin B6, Vitamin B12 and Vitamin Crecruiting2025296
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapyrecruiting202460
Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPArecruiting202429
THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMEScompleted202454
Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Diseaserecruiting2024150
Efficacy and Safety of Etoricoxib/Cyanocobalamin Versus Etoricoxib for Acute Low Back PainPhase 3completed2024190
Effect of a New Formulation of Vitamin B12 on Physical and Mentalrecruiting202418
Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia)Phase 1unknown202454
Vitamin B12 Status and Its Impact on Chronic Haemodialysis Patientunknown202460
Effect of Micronutrient Supplementation on Nerve Conduction Velocity in T1D- RCTunknown2024120
Hydroxocobalamin Approach for Reducing of Calprotectin With Butyrate for Ulcerative Colitis RemissionPhase 2withdrawn2024
Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedemaunknown2024200
Vitamin B12 and Folinic Acid Supplementation in Mitochondrial DNA Deletion SyndromesPhase 1unknown202425
Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girlscompleted2023472
Efficiency of a Composite Personalised Care on Functional Outcome in Early PsychosisPhase 3recruiting2023500
A Study on Hydroxocobalamin Given to Healthy Individual to Monitor SymptomsPhase 1completed202310
Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC PatientsPhase 2active not recruiting202354
Vitamin B12 Dose Escalation Trial in PregnancyPhase 1active not recruiting202350
Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correctioncompleted202344
Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Statusrecruiting202354
Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adultsunknown2023220
Quadruple Fortified Salt Trial in Indiaunknown20231000
Relationship Between Vitamins and Radiologic Stage in Knee Osteoarthritiscompleted2023104
SERUM VITAMIN B12 LEVELS IN PATIENTS WITH HEMORRHAGIC VS ISCHEMIC CEREBROVASCULAR EVENT.unknown2023100
Bioavailability of Vitamin B12 in Bread Using Fermented Faba Bean as B12 Source in Healthy Volunteers (BeanBread)unknown202325

Peer-reviewed studies (292)

PaperAuthorsJournalYearType
Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled TrialSingh SK et al.American journal of hematology2026Randomized Controlled Trial
Effect of NSAIDs, melatonin, vitamin D and vitamin B12 chronotherapy on postoperative recovery after third molar surgical extraction: A pilot randomized crossover placebo-controlled trialAbusamak M et al.Oral and maxillofacial surgery2026Randomized Controlled Trial
Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled TrialInsin P et al.Asian Pacific journal of cancer prevention : APJCP2026Randomized Controlled Trial
A two-center comparison of the efficacy of methylene blue and hydroxocobalamin for the treatment of refractory shockLeung NY et al.Perfusion2026Observational Study
Evaluating the Impact of a Standardized Protocol for Managing Refractory Vasoplegia After Cardiopulmonary BypassTeletnick A et al.Journal of cardiothoracic and vascular anesthesia2026Observational Study
Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trialReyes-Alvarez MT et al.Medicina clinica2026Randomized Controlled Trial
Efficacy of L-methylfolate and methylcobalamin in treating resistant hypertension associated with elevated serum homocysteine in hemodialysis patientsSalem MS et al.BMC nephrology2026Randomized Controlled Trial
Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT)Pathak BK et al.Clinical pediatrics2026Randomized Controlled Trial
Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trialda Mota JCNL et al.Clinical epigenetics2026Randomized Controlled Trial
Clinical safety of ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis: Open-label extension of a phase 2/3 randomized controlled studyKaji R et al.Journal of the neurological sciences2026Randomized Controlled Trial
Investigating the relationship between dietary vitamin B12 and bone mineral density: Observational and genetic analysesZhong Y et al.The Journal of nutritional biochemistry2026Observational Study
Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled studyChen CH et al.Journal of the Formosan Medical Association = Taiwan yi zhi2026Randomized Controlled Trial
Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?Wang X et al.BMC pregnancy and childbirth2025Observational Study
Effect of methylcobalamin on capecitabine induced hand-foot syndrome in patients with HER2 negative early breast cancer: multicentre, double blind, randomised, placebo controlled, phase 3 trialXia Y et al.BMJ (Clinical research ed.)2025Randomized Controlled Trial
Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers, Combined with Dapagliflozin as Type 2 Diabetes Mellitus Routine Treatment: A Controlled Randomized, Double-blind TrialAburayyan W et al.Iranian journal of medical sciences2025Randomized Controlled Trial
Use of Hydroxycobolamin in the Prevention of Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass: A Controlled Prospective TrialSalah D et al.Journal of cardiothoracic and vascular anesthesia2025Randomized Controlled Trial
Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in TanzaniaLweno O et al.Gates open research2024Clinical Study
Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trialHe C et al.Journal of orthopaedic surgery and research2024Randomized Controlled Trial
Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways(TM)) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled TrialPokushalov E et al.Nutrients2024Randomized Controlled Trial
A Randomized Control Trial of Dexketoprofen/Vitamin B (Thiamine, Pyridoxine and Cyanocobalamin) Fixed-Dose Combination in Post-Traumatic Grade I-II Cervical SprainsDelgado-García P et al.Clinical drug investigation2024Randomized Controlled Trial
Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trialGao Y et al.BMC oral health2024Randomized Controlled Trial
Serum vitamin B12, distal symmetrical polyneuropathy and anaemia in type 2 diabetes: the Fremantle Diabetes Study Phase 2Davis TME et al.Internal medicine journal2024Clinical Trial, Phase II
The effect of vitamin B12 on idiopathic tinnitusDadgarnia M et al.American journal of otolaryngology2024Randomized Controlled Trial
Bioavailability and daily requirement of vitamin B(12) in adult humans: an observational study of its colonic absorption and daily excretion as measured by [(13)C]-cyanocobalamin kineticsKurpad AV et al.The American journal of clinical nutrition2023Observational Study
Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trialBarlow-Mosha LN et al.Journal of the International AIDS Society2023Randomized Controlled Trial
Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairmentZhou L et al.Nutricion hospitalaria2023Randomized Controlled Trial
Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short statureSun F et al.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2023Randomized Controlled Trial
Vitamin B(12) status in infancy and the effect of a vitamin B(12) injection in infants with subclinical vitamin B(12) deficiency: study protocol for a register-based randomised controlled trialBakken KS et al.BMJ open2023Clinical Study
Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6-7 Years: A Follow-Up of a Randomized Controlled TrialManapurath R et al.The Journal of nutrition2023Randomized Controlled Trial
Effect of Laparoscopic Proximal Gastrectomy With Double-Tract Reconstruction vs Total Gastrectomy on Hemoglobin Level and Vitamin B12 Supplementation in Upper-Third Early Gastric Cancer: A Randomized Clinical TrialPark DJ et al.JAMA network open2023Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Cyanocobalamin (Vitamin B12)?

A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.

How many registered human trials study Cyanocobalamin (Vitamin B12)?

The PeptideWhiz trial index lists 201 registered trials for Cyanocobalamin (Vitamin B12), the most recent from 2026.

How much published research exists on Cyanocobalamin (Vitamin B12)?

The PeptideWhiz paper index links 292 PubMed papers to Cyanocobalamin (Vitamin B12); by study type, 452 human and 27 animal studies.

Which conditions is Cyanocobalamin (Vitamin B12) researched for?

Acid reflux and GERD, Dementia, Alzheimer's & cognitive decline, Fatigue & low energy (incl. midlife), Insulin resistance, prediabetes & type 2 diabetes, Lipedema, Anemia, Anti-aging & longevity, Atherosclerosis, cardiovascular disease & high blood pressure, Autism support, Bell's palsy, Carpal tunnel, Chronic and systemic inflammation, Chronic fatigue syndrome and ME, Cognition, focus & brain performance, Concussion, traumatic brain injury & stroke recovery, Diabetic retinopathy and glaucoma, Eczema, Eyes: macular degeneration & retinal health, Fat loss, obesity & body recomposition, Fatty liver & elevated liver enzymes, Gum disease (periodontal) & oral health, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, High cholesterol and statins, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney), Low blood pressure and orthostatic hypotension, Lung health, asthma & COPD, Lupus (SLE), Lymphedema and swelling, Menopause & perimenopause, Multiple sclerosis, Muscle disease (myopathy), Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Parkinson's disease, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Psoriasis and psoriatic arthritis, Rheumatoid arthritis, Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep problems (incl. insomnia on peptides), Thick blood and blood clots, Thyroid problems, Tinnitus.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).