What is Dihexa?
A small angiotensin IV-derived peptide mimetic that boosts HGF/c-Met signaling in animal memory models; no human trials published.
Dihexa in the library · · Human Trials · What are peptides?
0 registered trials · 0 indexed papers · 0 human / 7 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
Dihexa is described as a modified fragment of angiotensin IV developed at Washington State University. It was designed to cross the blood-brain barrier and to be orally active in animals.
It is popular in nootropic communities, but all published efficacy data come from animals and cells.
Mechanism (as described)
- It is described as binding hepatocyte growth factor (HGF) and helping it activate its receptor c-Met, a pathway tied to synapse formation (Wright et al., 2015).
- Because c-Met signaling is also involved in cell growth, researchers have raised theoretical cancer-risk questions; no long-term safety data exist.
Evidence (as described)
- Animal studies report improved memory in rodent models of cognitive impairment and protection in models such as Huntington's-like injury (Wells et al., 2024).
- No published human trial is on file.
Status
Not approved; preclinical only.
More cited research
- AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway (2021, animal)
- Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal (2021, animal)
- Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats (2024, animal)
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure (2015, animal)
Related compounds
- Colivelin
- FGL Peptide
- P21 (P021)
- PE-22-28
- Adamax
- Adipotide
- B7-33
- Bromantane (non-peptide)
- Cerebrolysin
- Cortagen
FAQ
What is Dihexa?
A small angiotensin IV-derived peptide mimetic that boosts HGF/c-Met signaling in animal memory models; no human trials published.
How many registered human trials study Dihexa?
The PeptideWhiz trial index lists 0 registered trials for Dihexa.
How much published research exists on Dihexa?
By study type, PeptideWhiz counts 0 human and 7 animal studies on Dihexa.
Which conditions is Dihexa researched for?
No condition pages are linked to this compound yet.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).