What is Cerebrolysin?

A mixed neurotrophic preparation (NGF-, BDNF-, GDNF- and CNTF-like activity).

Cerebrolysin in the library · · Human Trials · What are peptides?

40 registered trials · 87 indexed papers · 290 human / 238 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A mixed neurotrophic preparation (NGF-, BDNF-, GDNF- and CNTF-like activity). It's a full "growth-factor cocktail," not a single synthetic peptide.

Mechanism (as described)

Mimics the body's neurotrophic factors, telling damaged neurons to survive and repair. Drives neurogenesis and dendrite growth, and works well alongside raised IGF-1.

Additional points (as described)

MS: aids oligodendrocyte survival and remyelination.
Tinnitus: rewires auditory and limbic circuits, calms over-excited neurons and refuels the prefrontal cortex.

Registered human trials (40)

Trial	Phase	Status	Year	Enrolled
Combined Acupuncture-Based Therapy for Rehabilitation After Ischemic Stroke		not yet recruiting	2026	440
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy	Phase 2	not yet recruiting	2026	100
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study		recruiting	2025	30
Safety and Feasibility of Using Cerebrolysin in the Treatment of Primary Intracerebral Hemorrhage - a Prospective Randomized Open Blinded End-point Trial	Phase 4	not yet recruiting	2025	30
Cerebrolysin in Critically Ill Patients With Delirium		enrolling by invitation	2024	500
Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion	EARLY_Phase 1	unknown	2024	20
Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness	Phase 4	recruiting	2023	12
Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU	Phase 3	completed	2023	150
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy	Phase 1/Phase 2	recruiting	2023	90
CERebrolysin In CADASIL	Phase 2	active not recruiting	2023	30
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery		unknown	2023	100
CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke	Phase 4	unknown	2023	350
A Prospective, Trial About Safety and Efficacy of Combined Treatment With Cerebrolysin in Acute Ischemic Hemispheric Stroke Patients Undergoing EndoVascular Treatment (EVT)		unknown	2023	30
Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke	Phase 4	unknown	2022	60
Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants	Phase 4	completed	2021	160
Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke.	Phase 3	unknown	2021	50
IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE	Phase 2	terminated	2021	4
Early Administration of Cerebrolysin on the Outcome of Patients With Acute Stroke Undergoing EVT	Phase 2/Phase 3	unknown	2021	100
Effects of Cerebrolysin on Level of Consciousness and Brain Metabolism in Disorder of Consciousness After Stroke: Single Center Randomized Controlled Study	Phase 4	unknown	2021	30
Evaluation of the Effect of Neuroprotective Drug on Treatment Result in Patients After Traumatic Brain Injury		completed	2020	56
Cerebrolycin for Treatment of Covid-related Anosmia and Ageusia	Phase 3	completed	2020	250
Cerebrolysin REGistry Study in Stroke - a High-quality Observational Study of Comparative Effectiveness		completed	2018	1851
Cerebrolysin and Neurodevelopment in Preterm Infants	Phase 1	completed	2016	60
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome	Phase 2	completed	2016	64
Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke	Phase 4	completed	2016	80
Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm	Phase 4	unknown	2015	30
Cerebrolysin REGistry Study in Stroke		terminated	2014	1823
Hair Repigmentation During Cerebrolysin Therapy		completed	2014	5
Cerebrolysin Neural Repair Therapy in Children With Traumatic Brain Injury and Cerebral Palsy	Phase 2	unknown	2014	100
The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery	Phase 4	terminated	2013	46
Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage	Phase 2/Phase 3	completed	2013	50
Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT)	Phase 4	withdrawn	2013
Effects of Cerebrolysin on Motor Recovery in Patients With Subacute Stroke	Phase 4	completed	2011	71
Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy	Phase 2	completed	2011	40
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.	Phase 3	completed	2011	30
Dl-3-n-butylphthalide and Cerebrolysin Treatment in Acute Ischemic Stroke	Phase 1/Phase 2	completed	2010	84
A Clinical Trial to Evaluate the Safety and Efficacy of [amount hidden] Cerebrolysin in Patients With Vascular Dementia	Phase 4	completed	2006	242
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke	Phase 4	completed	2006	1071
Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke	Phase 3	completed	2005	119
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease	Phase 2	completed	2004	217

Peer-reviewed studies (87)

Paper	Authors	Journal	Year	Type
Evaluating the Effect of Cerebrolysin as an Adjuvant to Standard Therapy in Patients with Acute Ischemic Stroke: A Prospective Observational Study	Kandasamy G et al.	Medicina (Kaunas, Lithuania)	2025	Observational Study
[Cerebrolysin with reperfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CEREHETIS trial]	Kalinin MN et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2025	Randomized Controlled Trial
Efficacy of Cerebrolysin Treatment as an Add-On Therapy to Mechanical Thrombectomy in Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion in Anterior Circulation: Results of a 3-Month Follow-up of a Prospective, Open Label, Single-Center Study	Staszewski J et al.	Translational stroke research	2025	Clinical Trial, Phase III
[Cerebrolysin and the optimal timing of anticoagulation resumption in stroke: combined post hoc survival analysis of the CEREHETIS trial]	Kalinin MN et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2025	Randomized Controlled Trial
Speech Therapy Combined With Cerebrolysin in Enhancing Nonfluent Aphasia Recovery After Acute Ischemic Stroke: ESCAS Randomized Pilot Study	Homberg V et al.	Stroke	2025	Randomized Controlled Trial
[Cerebrolysin in the preventive therapy of dementia in elderly patients with mild cognitive impairment: a three-year prospective comparative study]	Ponomareva EV et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2024	Randomized Controlled Trial
Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study	Firstenfeld AJ et al.	Journal of medicine and life	2023	Randomized Controlled Trial
The effectiveness of cerebrolysin, a multi-modal neurotrophic factor, for treatment of post-covid-19 persistent olfactory, gustatory and trigeminal chemosensory dysfunctions: a randomized clinical trial	Hamed SA et al.	Expert review of clinical pharmacology	2023	Randomized Controlled Trial
[Effects of simultaneous use of Cerebrolysin and alteplase on hemorrhagic transformation of brain infarction and functional outcome in stroke patients: CEREHETIS, a randomized, multicenter pilot trial]	Khasanova DR et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2023	Randomized Controlled Trial
Cerebrolysin as an Early Add-on to Reperfusion Therapy: Risk of Hemorrhagic Transformation after Ischemic Stroke (CEREHETIS), a prospective, randomized, multicenter pilot study	Khasanova DR et al.	BMC neurology	2023	Randomized Controlled Trial
Extended Poststroke Rehabilitation Combined with Cerebrolysin Promotes Upper Limb Motor Recovery in Early Subacute Phase of Rehabilitation: A Randomized Clinical Study	Mitrović SZ et al.	Medicina (Kaunas, Lithuania)	2023	Randomized Controlled Trial
Prospective Randomized Control Trial to Compare the Role of Injection Cerebrolysin for 10 Days Duration Against Placebo in Operated Cases of Degenerative Cervical Myelopathy	Sharma A et al.	Spine	2023	Randomized Controlled Trial
Modulation of Amyloid-β and Tau in Alzheimer's Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil	Alvarez XA et al.	Journal of Alzheimer's disease : JAD	2022	Randomized Controlled Trial
Prospective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy	Sharma A et al.	Spine	2022	Randomized Controlled Trial
Effect of cerebrolysin on neurodevelopmental outcome of high risk preterm infants: A randomized controlled trial	Samir A et al.	Journal of neonatal-perinatal medicine	2022	Randomized Controlled Trial
Efficacy and safety of Cerebrolysin after futile recanalisation therapy in patients with severe stroke	Poljakovic Z et al.	Clinical neurology and neurosurgery	2021	Controlled Clinical Trial
Randomized, placebo-controlled, double-blind, pilot trial to investigate safety and efficacy of Cerebrolysin in patients with aneurysmal subarachnoid hemorrhage	Woo PYM et al.	BMC neurology	2020	Randomized Controlled Trial
The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury	Birle C et al.	Journal of medicine and life	2020	Randomized Controlled Trial
Efficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial	Muresanu DF et al.	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology	2020	Randomized Controlled Trial
Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial	Poon W et al.	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology	2020	Randomized Controlled Trial
Role of Cerebrolysin in cervical spondylotic myelopathy patients: a prospective randomized study	Allam AFA et al.	The spine journal : official journal of the North American Spine Society	2018	Randomized Controlled Trial
Cerebrolysin and early neurorehabilitation in patients with acute ischemic stroke: a prospective, randomized, placebo-controlled clinical study	Stan A et al.	Journal of medicine and life	2017	Randomized Controlled Trial
[Monitoring of neurotrophic factors and cognitive function in patients with traumatic brain injury]	Karakulova YV et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2017	Randomized Controlled Trial
Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial	Gharagozli K et al.	Journal of medicine and life	2017	Randomized Controlled Trial
Effect of cerebrolysin on gross motor function of children with cerebral palsy: a clinical trial	Nasiri J et al.	Acta neurologica Belgica	2017	Randomized Controlled Trial
[Effect of cerebrolysin on remyelination processes in multiple sclerosis patients in stage of relapse regression]	Khabirov FA et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2016	Randomized Controlled Trial
[Comparative dynamics of EEG parameters in elderly depressive patients during monotherapy and combined therapy]	Iznak AF et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2016	Randomized Controlled Trial
Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke	Chang WH et al.	BMC neurology	2016	Randomized Controlled Trial
Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial	Muresanu DF et al.	Stroke	2016	Randomized Controlled Trial
[An assessment of cerebrolysin effect on BDNF level in patients with post stroke aphasia depending on carbohydrate metabolism disorders]	Shishkova VN et al.	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova	2015	Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Cerebrolysin?

A mixed neurotrophic preparation (NGF-, BDNF-, GDNF- and CNTF-like activity).

How many registered human trials study Cerebrolysin?

The PeptideWhiz trial index lists 40 registered trials for Cerebrolysin, the most recent from 2026.

How much published research exists on Cerebrolysin?

The PeptideWhiz paper index links 87 PubMed papers to Cerebrolysin; by study type, 290 human and 238 animal studies.

Which conditions is Cerebrolysin researched for?

Multiple sclerosis, Concussion, traumatic brain injury & stroke recovery, Dementia, Alzheimer's & cognitive decline, Cognition, focus & brain performance, Tinnitus, Autism support, Anti-aging & longevity, Bell's palsy, Atherosclerosis, cardiovascular disease & high blood pressure, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Neuropathy and CRPS, Post-surgical inflammation and surgery recovery.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research