What is P21 (P021)?
A small ciliary neurotrophic factor (CNTF)-derived peptide mimetic studied for neurogenesis in animal models.
P21 (P021) in the library · · Human Trials · What are peptides?
0 registered trials · 0 indexed papers · 16 human / 86 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
P21 (P021) is described as a short peptide derived from an active region of CNTF, with an adamantane group added to help it reach the brain. It came out of research on Cerebrolysin-related neurotrophic fragments.
All published work is in cells and animals.
Mechanism (as described)
- It is described as increasing BDNF expression and supporting neurogenesis and synaptic plasticity in mouse models (Kazim et al., 2016; Baazaoui et al., 2017).
Evidence (as described)
- Animal models of Alzheimer's disease and CDKL5 deficiency disorder reported improved synaptic markers or behavior (Mottolese et al., 2024).
- No human trial is on file.
Status
Not approved; preclinical only.
More cited research
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma (2026, human observational)
- [Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6 (2024, human observational)
- Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling (2018, human observational)
- Insulin priming effect on estradiol-induced breast cancer metabolism and growth (2015, human observational)
- Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocell (2020, animal)
- Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition (2008, animal)
- Effect of Zinc Status on Pubertal and Cognitive Functions in Male Offspring of Rats with Induced Zinc Deficiency During Gestation and Lactation (2026, animal)
- Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells (2026, animal)
Related compounds
FAQ
What is P21 (P021)?
A small ciliary neurotrophic factor (CNTF)-derived peptide mimetic studied for neurogenesis in animal models.
How many registered human trials study P21 (P021)?
The PeptideWhiz trial index lists 0 registered trials for P21 (P021).
How much published research exists on P21 (P021)?
By study type, PeptideWhiz counts 16 human and 86 animal studies on P21 (P021).
Which conditions is P21 (P021) researched for?
No condition pages are linked to this compound yet.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).