What is Enclomiphene (non-peptide SERM)?

A selective estrogen-receptor modulator.

Enclomiphene (non-peptide SERM) in the library · · Human Trials · What are peptides?

19 registered trials · 5 indexed papers · 37 human / 35 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A selective estrogen-receptor modulator. It blocks estrogen feedback at the hypothalamus and pituitary, so the brain raises GnRH, LH and FSH and the testes produce more.

Registered human trials (19)

Trial	Phase	Status	Year	Enrolled
A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With [amount hidden] Enclomiphene	Phase 2	completed	2016	50
Androxal in Male Infertility	Phase 2/Phase 3	withdrawn	2014
Assessment of Drug-Drug Interactions of Androxal With Cytochrome P450 Isoenyzmes in Healthy Males	Phase 1	completed	2014	30
Comparison of Two Formulations of Androxal	Phase 1	completed	2013	16
Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function	Phase 1	completed	2013	26
A Dose Escalating Study to Determine the Tolerability and PK of a Single Dose of Androxal	Phase 1	completed	2013	9
Evaluation of the Pharmacokinetics and Safety of Androxal in Male Subjects With Impaired Hepatic Function	Phase 1	completed	2013	19
Phase III Study to Evaluated Morning Testosterone Normalization in Men With Secondary Hypogonadism	Phase 3	completed	2012	151
Phase III Study to Evaluate Morning Testosterone Normalization in Overweight Men With Secondary Hypogonadism	Phase 3	completed	2012	181
Assessment of the Effects of Enclomiphene Citrate on Bone Mineral Density in Men With Secondary Hypogonadism	Phase 3	completed	2012	300
Safety Study of Enclomiphene Citrate in the Treatment of Men With Secondary Hypogonadism	Phase 3	completed	2012	499
An Extension Study of Enclomiphene Citrate in the Treatment of Men With Secondary Hypogonadism	Phase 3	completed	2012	300
The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone)	Phase 2	completed	2011	60
Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism	Phase 2	completed	2011	83
A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203	Phase 2	completed	2011	48
Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes Mellitus	Phase 2	completed	2010	102
To Evaluate Sperm Parameters in Men With Secondary Hypogonadism Previously Treated With Topical Testosterone	Phase 2	completed	2008	17
Study to Evaluate the Safety and Efficacy of Androxal Treatment in Men With Secondary Hypogonadism	Phase 3	completed	2006	104
Study to Evaluate the Safety and Efficacy of Androxal™ Treatment in Men With Secondary Hypogonadism	Phase 3	completed	2006	194

Peer-reviewed studies (5)

Paper	Authors	Journal	Year	Type
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement	Kim ED et al.	BJU international	2016	Randomized Controlled Trial
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone	Wiehle RD et al.	Fertility and sterility	2014	Randomized Controlled Trial
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel	Kaminetsky J et al.	The journal of sexual medicine	2013	Randomized Controlled Trial
Single-dose pharmacokinetic study of clomiphene citrate isomers in anovular patients with polycystic ovary disease	Ghobadi C et al.	Journal of clinical pharmacology	2009	Clinical Trial
Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate	Ghobadi C et al.	Fertility and sterility	2009	Clinical Trial

More cited research

Changes in Serum Testosterone After Sublingual Enclomiphene Citrate Combined With a Mineral Oxide Delivery System: A Retrospective Case Series of 15 Men (2026, human observational)
Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report (2026, human observational)
Safety and efficacy of enclomiphene and clomiphene for hypogonadal men (2024, human observational)
Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study (2023, human observational)
Clomiphene Citrate and Enclomiphene Hydrochloride Exposure Is Associated With Interfrontal Suture Fusion in Zebrafish (2023, animal)
Differential responses of estrogen target tissues in rats including bone to clomiphene, enclomiphene, and zuclomiphene (1998, animal)
Effects of enclomiphene and zuclomiphene on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of small and large ovine luteal (1996, animal)
Enclomiphene does not alter the postpartum interval of suckled beef cows (1991, animal)

Conditions researched

Related compounds

FAQ

What is Enclomiphene (non-peptide SERM)?

A selective estrogen-receptor modulator.

How many registered human trials study Enclomiphene (non-peptide SERM)?

The PeptideWhiz trial index lists 19 registered trials for Enclomiphene (non-peptide SERM), the most recent from 2016.

How much published research exists on Enclomiphene (non-peptide SERM)?

The PeptideWhiz paper index links 5 PubMed papers to Enclomiphene (non-peptide SERM); by study type, 37 human and 35 animal studies.

Which conditions is Enclomiphene (non-peptide SERM) researched for?

Low testosterone (without or alongside TRT), Sexual function & libido (women and men), Muscle gain, sarcopenia & building muscle after 40, Eyes: macular degeneration & retinal health, Fat loss, obesity & body recomposition, Female fertility, Insulin resistance, prediabetes & type 2 diabetes, Male fertility and sperm.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).